4,4'-二甲基二苯胺合成路线 （共 114 条）
反应条件
ammonia; copper (II) acetate monohydrate; benzoic acid in water; propionic acid ethyl ester T=80°C; 24 h;
参考文献
Zhou, Changfeng; Chen, Fan; Yang, Dongpeng; Jia, Xiaofei; Zhang, Lixue; Cheng, Jiang
Chemistry Letters, 2009 , vol. 38, # 7 p. 708 - 709
反应条件
water; potassium hydroxide in 3-methyl-1-butanol
参考文献
US7829639 B2, ;
Page/Page column 60 ;
反应条件
potassium phosphate; copper(l) iodide; lithium amide in N,N-dimethyl-formamide T=130°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Tlili, Anis; Monnier, Florian; Taillefer, Marc
Chemical Communications, 2012 , vol. 48, # 51 p. 6408 - 6410
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene; sodium t-butanolate in toluene T=110°C; Buchwald-Hartwig coupling; 24 h; Inert atmosphere;
参考文献
Liu, Han; Wang, Neng-Dong; Du, Da-Ming
Letters in Organic Chemistry, 2010 , vol. 7, # 2 p. 114 - 120
反应条件
copper diacetate; triethylamine in dichloromethane T=40°C; Ullmann condensation; 6 h; In air;
参考文献
Qin, Weiwei; Kakusawa, Naoki; Wu, Yichen; Yasuike, Shuji; Kurita, Jyoji
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 4 p. 436 - 438
反应条件
1: With caesium carbonate; chloroacetyl chloride in N,N-dimethyl-formamide T=20°C; Smiles rearrangement; 0.5 h; 2: in N,N-dimethyl-formamide T=150°C; Smiles rearrangement; Microwave irradiation;
参考文献
Tian, Xiao; Wu, Ren-Min; Liu, Gang; Li, Zhu-Bo; Wei, He-Lin; Yang, Hao; Shin, Dong-Soo; Wang, Li-Ying; Zuo, Hua
Arkivoc, 2011 , vol. 2011, # 10 p. 118 - 126
反应条件
copper(l) iodide; N,N,N',N,-tetramethylethylenediamine in toluene 3 h; Heating;
参考文献
Matsuo, Koji; Shichida, Yoshiaki; Nishida, Hiroshi; Nakata, Satsuki; Okubo, Masao
Journal of Physical Organic Chemistry, 1994 , vol. 7, p. 9 - 17
反应条件
copper diacetate in dichloromethane 2 h; Ambient temperature;
参考文献
Barton, Derek H. R.; Donnelly, Dervilla, M. X.; Finet, Jean-Pierre; Guiry, Patrick J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 9 p. 2095 - 2102
反应条件
hydrogen; nickel in methanol
参考文献
European Journal of Medicinal Chemistry, , vol. 18, # 1 p. 35 - 40
反应条件
potassium tert-butylate; urea; biphenyl-2-yl-di-tert-butyl-phosphane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in 1,4-dioxane T=100°C; 21 h; Product distribution; Further Variations:Reagentstime;
参考文献
Synlett, , # 2 p. 235 - 238
