4,4'-二甲基二苯胺合成路线 （共 114 条）
反应条件
2: mCPBA 3: p-TosOH / CCl4 / Heating View Scheme
参考文献
Hou, Yankun; Higashiya, Seiichiro; Fuchigami, Toshio
Journal of Organic Chemistry, 1997 , vol. 62, # 25 p. 8773 - 8776
反应条件
1.1: hydrogenchloride / ethanol; water / 0.08 h / 0 °C 1.2: 1.08 h / 0 °C 2.1: lithium aluminium tetrahydride / diethyl ether / 3 h View Scheme
参考文献
Tonks, Ian A.; Durrell, Alec C.; Gray, Harry B.; Bercaw, John E.
Journal of the American Chemical Society, 2012 , vol. 134, # 17 p. 7301 - 7304
反应条件
bromine in methanol; dichloromethane T=0°C;
参考文献
Wanniarachchi, Sarath; Liddle, Brendan J.; Lindeman, Sergey V.; Gardinier, James R.
Journal of Organometallic Chemistry, 2011 , vol. 696, # 23 p. 3623 - 3636
反应条件
potassium tert-butylate; [2,6-iPr2C6H3N=C(H)C(H)=NC6H3-2,6-iPr2]; copper(l) iodide in toluene T=120°C; 20 h;
参考文献
Liu, Yu-Hua; Chen, Chen; Yang, Lian-Ming
Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9275 - 9278
反应条件
KOH; copper(l) chloride in toluene
参考文献
NATIONAL TSING HUA UNIVERSITY
Patent: US2013/1521 A1, 2013 ;
反应条件
1: 4,4'-dimethyldiphenylamine With ethylmagnesium bromide in diethyl ether T=0 - 40°C; 2 h; Inert atmosphere; 2: bromobenzene With lithium bromide; iron(II) chloride in anhydrous xylene T=140°C; 72 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Imayoshi, Ryuji; Yoshimoto, Yuya; Ghorai, Sujit K.; Jin, Masayoshi; Takaya, Hikaru; Norisuye, Kazuhiro; Sohrin, Yoshiki; Nakamura, Masaharu
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20262 - 20265
反应条件
1: 4,4'-dimethyldiphenylamine With Ni(PCy3)2Cl2; isopropylmagnesium chloride; tri-cyclo-hexyl-phosphine in tetrahydrofuran; 1,4-dioxane T=20°C; 0.0833333 h; Inert atmosphere; 2: chlorobenzene in tetrahydrofuran; 1,4-dioxane T=20 - 95°C; 12.16 h; Inert atmosphere;
参考文献
Li, Xin-Le; Wu, Wei; Fan, Xin-Heng; Yang, Lian-Ming
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1232 - 1236
反应条件
toluene-4-sulfonic acid in toluene 12 h; Heating;
参考文献
Haga, Kazuo; Iwaya, Katsumasa; Kaneko, Ryohei
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 3 p. 803 - 808
反应条件
sodium tert-pentoxide; palladium diacetate; 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.1(3,7)]decane in toluene T=20 - 90°C; 1.58333 - 1.83333 h;
参考文献
US2008/125608 A1, ;
Page/Page column 8 ;
反应条件
potassium tert-butylate; [2,6-iPr2C6H3N=C(H)C(H)=NC6H3-2,6-iPr2]; copper(l) iodide in toluene T=120°C; 20 h;
参考文献
Tetrahedron Letters, , vol. 47, # 52 p. 9275 - 9278
