sodium hydroxide in 1,4-dioxane; water 1 h; Ambient temperature;

1: CH2Cl2 / 480 h / 20 °C 2: 1.) HCl, 2.) H2O / 1.) diethyl ether, below 5 deg C, 24h, 2.) below 10 deg C 3: 100 percent / NaOH / dioxane; H2O / 1 h / Ambient temperature View Scheme

1: 1.) HCl, 2.) H2O / 1.) diethyl ether, below 5 deg C, 24h, 2.) below 10 deg C 2: 100 percent / NaOH / dioxane; H2O / 1 h / Ambient temperature View Scheme

Multistep reaction;