(2S,3s)-3-氨基-2-羟基-4-苯基丁酸合成路线 （共 15 条）
参考文献
Takita,T. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 510 - 515
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran; methanol T=0°C; 2: With triethylamine in dichloromethane T=0°C; 1 h; 3: With p-toluenesulfonyl chloride in dichloromethane T=0°C; 1 h;
参考文献
The Scripps Research Institute
Patent: US6900238 B1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
lithium hydroxide in methanol; water
0.5 h; Ambient temperature;
参考文献
Slee; Slee, Deborah H.; Laslo; Laslo, Karen L.; Elder; Elder, John H.; Ollmann; Ollmann, Ian R.; Gustchina; Gustchina, Alla; Kervinen; Kervinen, Jukka; Zdanov; Zdanov, Alexander; Wlodawer; Wlodawer, Alexander; Wong; Wong, Chi-Huey
Journal of the American Chemical Society, 1995 , vol. 117, # 48 p. 11867 - 11878
反应条件
1: With lithium hydroxide; water in methanol
T=20°C; 0.5 h;
2: With hydrogenchloride in methanol; water
pH=2.0 - 7.0;
参考文献
The Scripps Research Institute
Patent: US6900238 B1, 2005 ;
Location in patent: Page/Page column 22-23 ;
反应条件
sodium hydroxide in 1,4-dioxane
1 h; Ambient temperature;
参考文献
Herranz, Rosario; Castro-Pichel, Julia; Garcia-Lopez, Teresa
Synthesis, 1989 , # 9 p. 703 - 706
反应条件
1: O3 / CH2Cl2
2: NaBH4 / methanol / 0.33 h / 0 °C
3: 92 percent / 0.25 N LiOH / methanol; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Slee; Slee, Deborah H.; Laslo; Laslo, Karen L.; Elder; Elder, John H.; Ollmann; Ollmann, Ian R.; Gustchina; Gustchina, Alla; Kervinen; Kervinen, Jukka; Zdanov; Zdanov, Alexander; Wlodawer; Wlodawer, Alexander; Wong; Wong, Chi-Huey
Journal of the American Chemical Society, 1995 , vol. 117, # 48 p. 11867 - 11878
反应条件
1: NaBH4 / methanol / 0.33 h / 0 °C
2: 92 percent / 0.25 N LiOH / methanol; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Slee; Slee, Deborah H.; Laslo; Laslo, Karen L.; Elder; Elder, John H.; Ollmann; Ollmann, Ian R.; Gustchina; Gustchina, Alla; Kervinen; Kervinen, Jukka; Zdanov; Zdanov, Alexander; Wlodawer; Wlodawer, Alexander; Wong; Wong, Chi-Huey
Journal of the American Chemical Society, 1995 , vol. 117, # 48 p. 11867 - 11878
反应条件
1: t-BuLi, MgBr2 / tetrahydrofuran
2: O3 / CH2Cl2
3: NaBH4 / methanol / 0.33 h / 0 °C
4: 92 percent / 0.25 N LiOH / methanol; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Slee; Slee, Deborah H.; Laslo; Laslo, Karen L.; Elder; Elder, John H.; Ollmann; Ollmann, Ian R.; Gustchina; Gustchina, Alla; Kervinen; Kervinen, Jukka; Zdanov; Zdanov, Alexander; Wlodawer; Wlodawer, Alexander; Wong; Wong, Chi-Huey
Journal of the American Chemical Society, 1995 , vol. 117, # 48 p. 11867 - 11878
反应条件
1: 95 percent / p-toluenesulphonic acid / CH2Cl2 / Heating
2: BF3*Et2O / CH2Cl2 / 2 h / Ambient temperature
3: 1.) pyridinium chlorochromate; 2.) HCl / 2.) Et2O, 4 deg C, 24 h
4: NaOH / dioxane; H2O
View Scheme
参考文献
Herranz, Rosario; Castro-Pichel, Julia; Vinuesa, Soledad; Garcia-Lopez, Ma. Teresa
Journal of the Chemical Society, Chemical Communications, 1989 , # 14 p. 938 - 939
反应条件
1: BF3*Et2O / CH2Cl2 / 2 h / Ambient temperature
2: 1.) pyridinium chlorochromate; 2.) HCl / 2.) Et2O, 4 deg C, 24 h
3: NaOH / dioxane; H2O
View Scheme
参考文献
Herranz, Rosario; Castro-Pichel, Julia; Vinuesa, Soledad; Garcia-Lopez, Ma. Teresa
Journal of the Chemical Society, Chemical Communications, 1989 , # 14 p. 938 - 939
