6-(2-羟基乙基)-5-甲基[1,2,4]三唑并[1,5-a]嘧啶-7(1H)-酮合成路线 （共 5 条）
反应条件
boron trifluoride diethyl etherate in isopropyl mesylate T=20°C; 72.25 h;
参考文献
WO2011/42496 A1, ;
Page/Page column 7-8 ;
WO 2011/042496 A1
反应条件
triethylamine in water 18 h; Ambient temperature;
参考文献
Sato, Yasunobu; Shimoji, Yasuo; Fujita, Hiroshi; Nishino, Hiroshi; Mizuno, Hiroshi; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 927 - 937
反应条件
1: 88 percent / BF3*MeOH / ethanol / 72 h / Ambient temperature 2: 89 percent / Et3N / H2O / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 8 p. 927 - 937
反应条件
1: 78 percent / POCl3 / 3 h / Heating
2: 70 percent / Na2CO3 / ethanol / 2 h / Heating
View Scheme
参考文献
Sato, Yasunobu; Shimoji, Yasuo; Fujita, Hiroshi; Nishino, Hiroshi; Mizuno, Hiroshi; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 927 - 937
反应条件
trichlorophosphate
3 h; Heating;
参考文献
Sato, Yasunobu; Shimoji, Yasuo; Fujita, Hiroshi; Nishino, Hiroshi; Mizuno, Hiroshi; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 927 - 937
