3-甲酰基-2-丁烯酸乙酯合成路线 （共 46 条）
反应条件
sodium methylate; triphenylphosphine hydrobromide; N,N-dimethyl-formamide weiteres Reagens: methanol. KOH; Reaktion ueber mehrere Stufen;
参考文献
BASF
Patent: DE1068710 , 1958 ;
反应条件
potassium hydroxide; sodium methylate 1.) dichloromethane, methanol, 0 deg C, 90 min, 2.) methanol, water, reflux, 45 min; Yield given. Multistep reaction;
参考文献
Rosenberger
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
反应条件
1: dichloromethane / 0 °C / |Inert atmosphere 2: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Billedeau, Roland J.; Klein, Klara R.; Kaplan, Daniel; Lou, Yan
Organic Letters, 2013 , vol. 15, # 7 p. 1421 - 1423
反应条件
1: 1.) ethylmagnesium bromide / 1.) THF, room temperature, 1 h, 2.) THF, 15 min 2: DIBAH / tetrahydrofuran; toluene / 0.5 h / -78 °C 3: 95 percent / imidazole / dimethylformamide / 18 h / Ambient temperature 4: H2 / Lindlar catalyst / methanol / 24 h 5: LiAlH4, TiCl3 / tetrahydrofuran / 1 h / Ambient temperature 6: 80 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature 7: MnO2 / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Solladie, Guy; Girardin, Andre
Tetrahedron Letters, 1988 , vol. 29, # 2 p. 213 - 216
反应条件
sodium methylate; triphenylphosphine hydrobromide; N,N-dimethyl-formamide weiteres Reagens: methanol. KOH; Reaktion ueber mehrere Stufen;
参考文献
BASF
Patent: DE1068710 , 1958 ;
反应条件
in dichloromethane T=20°C; Wittig reaction; 15 h;
参考文献
Li, Pengfei; Li, Jun; Arikan, Fatih; Ahlbrecht, Wiebke; Dieckmann, Michael; Menche, Dirk
Journal of the American Chemical Society, 2009 , vol. 131, # 33 p. 11678 - 11679
反应条件
benzoic acid in benzene Heating;
参考文献
Farmer, Luc J.; Marron, Kristen S.; Canan Koch, Stacie S.; Hwang; Kallel, E. Adam; Zhi, Lin; Nadzan, Alex M.; Robertson, Dave W.; Bennani, Youssef L.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2352 - 2356
反应条件
in dichloromethane T=20°C; Wittig reaction; 15 h; stereoselective reaction;
参考文献
Li, Pengfei; Li, Jun; Arikan, Fatih; Ahlbrecht, Wiebke; Dieckmann, Michael; Menche, Dirk
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2429 - 2444
反应条件
in various solvent(s) 15 h; Heating;
参考文献
Le Baut; Sparfel; Clairc; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 447 - 455
反应条件
sodium methylate; triphenylphosphine hydrobromide; N,N-dimethyl-formamide weiteres Reagens: methanol. KOH; Reaktion ueber mehrere Stufen;
