1: 4-hydroxy-2-(2-hydroxyethyl)-2-(3-methoxyphenyl)butanenitrile With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine in ethyl acetate T=-30°C; 2: methylamine With N-ethyl-N,N-diisopropylamine T=-30 - 20°C;