(R)-1-N-苄氧羰基-2-氰基吡咯烷合成路线 (共 2 条)
反应条件
pyridine; p-toluenesulfonyl chloride in dichloromethane T=20°C; 72 h;
参考文献
Cobb, Alexander J. A.; Shaw, David M.; Longbottom, Deborah A.; Gold, Johan B.; Ley, Steven V.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 1 p. 84 - 96
反应条件
1.1: 1-hydroxybenzotriazole; EDCI / tetrahydrofuran / 0.5 h / 20 °C 1.2: 68 percent / aq. NH3 / tetrahydrofuran / 24 h / 20 °C 2.1: 64 percent / p-TsCl; pyridine / CH2Cl2 / 72 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 1 p. 84 - 96