4-(氨甲基)-4-氟哌啶-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
1 Pd/C; hydrogen in methanol T=20°C; P=3450.35 Torr; 16 h;
参考文献
Verniest, Guido; Piron, Karel; Van Hende, Eva; Thuring, Jan Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 11 p. 2509 - 2512
反应条件
hydrazine in ethanol T=20°C; 2 h;
参考文献
EP1505067 A1, ;
Page/Page column 369 ;
EP 1505067 A1
参考文献
Verniest, Guido; Piron, Karel; Van Hende, Eva; Thuring, Jan Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 11 p. 2509 - 2512
反应条件
1: pyridinium poly(hydrogen fluoride) / dichloromethane / -10 - 20 °C 2: pyridine / 0 - 20 °C 3: N,N-dimethyl-formamide / 12 h / 150 °C 4: ethanolamine / 2.5 h / 60 °C View Scheme
反应条件
1: pyridine / 0 - 20 °C 2: N,N-dimethyl-formamide / 12 h / 150 °C 3: ethanolamine / 2.5 h / 60 °C View Scheme
反应条件
1: N,N-dimethyl-formamide / 12 h / 150 °C 2: ethanolamine / 2.5 h / 60 °C View Scheme
参考文献
US2011/256064 A1, ;
EP2377860 A1, ;
