(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺合成路线 （共 16 条）
反应条件
1.1: pyridine; thionyl chloride / tetrahydrofuran / -45 °C / Inert atmosphere 2.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 3.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
in tetrahydrofuran
Inert atmosphere;
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: lithium amide; ammonia / -60 - 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1: C32H41ClN2O4S2 With hydrogenchloride; water in methanol
T=20°C; 3 h;
2: (2S,3S)-2,3-dihydroxybutanedioic acid in water; acetone
T=60 - 70°C;
参考文献
Han, Zhengxu; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 327 - 333
反应条件
1: sodium hydrogencarbonate / ethyl acetate / Inert atmosphere
2: tetrahydrofuran / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1: sodium hydrogencarbonate / ethyl acetate / Inert atmosphere
2: tetrahydrofuran / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
lithium amide; ammonia
T=-60 - 20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
lithium amide; ammonia
T=-60 - 20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
