(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺合成路线 (共 16 条)
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: lithium amide; ammonia / -60 - 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484