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63148-62-9
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
620627-47-6
合成路线
(共 10 条)
620627-47-6
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
247089-85-6
(R)-(-)-4-甲基苯亚磺酰胺
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
反应条件
1.1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: lithium amide; ammonia / -60 - 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
247089-85-6
(R)-(-)-4-甲基苯亚磺酰胺
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
36321-90-1
溴(2-甲氧基-1-萘基)镁
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
1310105-69-1
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
95184-07-9
3-甲基-2-噻吩基溴化镁
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
1310105-72-6
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
873-77-8
4-氯苯基溴化镁
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
16750-63-3
2-甲氧基苯基溴化镁
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
1310105-65-7
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
108894-99-1
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
592507-77-2
反应条件
1.1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: lithium amide; ammonia / -60 - 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
2633-66-1
2,4,6-三甲基苯溴化镁
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
446021-73-4
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484
620627-47-6
+
82214-69-5
2-联苯基溴化镁
→
反应条件
620627-46-5
(R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺
+
1310105-66-8
反应条件
1.1: tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme
参考文献
Han, Zhengxu S.; Meyer, Angelica M.; Xu, Yibo; Zhang, Yongda; Busch, Robert; Shen, Sherry; Grinberg, Nelu; Lu, Bruce Z.; Krishnamurthy, Dhileep; Senanayake, Chris H.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5480 - 5484