4-(4-硝基苯基)-3-氧代丁酸乙酯合成路线 （共 10 条）
参考文献
Soliman; West
Journal of the Chemical Society, 1944 , p. 53
反应条件
1: 2.) Et3N / 1.) benzene, RT, 3 h, 2.) n-BuOH, reflux, 40 min 2: 74.4 percent / SeO2 / dioxane; H2O / 4 h / Heating 3: 92.2 percent / aq. NaOH / ethanol / 0.17 h / 40 °C 4: thionyl chloride, DMF / CH2Cl2 / 2 h 5: CH2Cl2 / 0.5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 6 p. 1279 - 1285
反应条件
pyridine
1.) CH2Cl2, RT, 1 h, 2.) reflux, 1 h; Yield given. Multistep reaction;
参考文献
Ohkubo; Kuno; Sakai; Sugiyama; Takasugi
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1279 - 1285
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran
参考文献
Kori, Masakuni; Miki, Takashi; Nishimoto, Tomoyuki; Tozawa, Ryuichi
Patent: US2003/78251 A1, 2003 ;
反应条件
1.1: SOCl2 / CH2Cl2 / 2 h / Heating
2.1: DIEA / CH2Cl2 / 4 h / 0 - 20 °C
2.2: 5.30 g / CH2Cl2 / 2 h / Heating
View Scheme
参考文献
Terai, Takuya; Kikuchi, Kazuya; Iwasawa, Shin-Ya; Kawabe, Takao; Hirata, Yasunobu; Urano, Yasuteru; Nagano, Tetsuo
Journal of the American Chemical Society, 2006 , vol. 128, # 21 p. 6938 - 6946
反应条件
sodium hydride; acetic acid in 1,4-dioxane
T=100°C; 1.5 h;
参考文献
Buss,C.W.; Coe,P.L.; Tatlow,J.C.
Journal of Fluorine Chemistry, 1986 , vol. 34, p. 83
反应条件
diethyl ether; magnesium diethoxide
Erwaermen des Reaktionsprodukts mit Toluol-sulfonsaeure-(4) in Benzol;
参考文献
Miller et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 500
反应条件
2 h; Heating / reflux;
参考文献
Japan Science and Technology Agency
Patent: EP1623979 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
[2,2']bipyridinyl
1) THF, (-70) - (-5) deg C; 2) THF, (-55) - (-70) deg C, 10 min; Yield given. Multistep reaction;
参考文献
Buss,C.W.; Coe,P.L.; Tatlow,J.C.
Journal of Fluorine Chemistry, 1986 , vol. 34, p. 83
反应条件
benzene
anschliessendes Behandeln mit wss. Ammoniak;
参考文献
Soliman; West
Journal of the Chemical Society, 1944 , p. 53
