2-甲基3-(三氟甲基)苯甲酸合成路线 (共 4 条)
反应条件
1: sulfuric acid / Reflux 2: N-bromosuccinmide / dibenzoyl peroxide / benzene / 52 h / 20 °C / Reflux; Inert atmosphere View Scheme
参考文献
Ruchelman, Alexander L.; Man, Hon-Wah; Zhang, Weihong; Chen, Roger; Capone, Lori; Kang, Jian; Parton, Anastasia; Corral, Laura; Schafer, Peter H.; Babusis, Darius; Moghaddam, Mehran F.; Tang, Yang; Shirley, Michael A.; Muller, George W.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 360 - 365
反应条件
sulfuric acid Reflux;
参考文献
Berthel, Steven Joseph; Kester, Robert Francis; Orzechowski, Lucja
Patent: US2012/283271 A1, 2012 ;
Location in patent: Page/Page column 10 ;
US 20120283271 A1
反应条件
sodium hydrogencarbonate
参考文献
Ruchelman, Alexander L.; Man, Hon-Wah; Zhang, Weihong; Chen, Roger; Capone, Lori; Kang, Jian; Parton, Anastasia; Corral, Laura; Schafer, Peter H.; Babusis, Darius; Moghaddam, Mehran F.; Tang, Yang; Shirley, Michael A.; Muller, George W.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 360 - 365
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
T=25°C; 1 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; YOSHIMOTO, Yuya; TAKAHASHI, Teruki; OOHIRA, Daisuke; AZUMA, Shuhei
Patent: WO2013/162077 A1, 2013 ;
Location in patent: Paragraph 0508 ;