1-(甲氧基甲氧基)-3-丙基苯合成路线 （共 5 条）
反应条件
hydrogen; sodium hydrogencarbonate; palladium 10 on activated carbon in ethanol; ethyl acetate
T=20°C; 20 h;
参考文献
Wyeth
Patent: US2003/207927 A1, 2003 ;
Location in patent: Page/Page column 14 ;
US 20030207927 A1
反应条件
palladium on activated charcoal; sodium hydrogencarbonate in ethanol; ethyl acetate
T=20°C; 20 h;
参考文献
Malamas, Michael S.; Manas, Eric S.; McDevitt, Robert E.; Gunawan, Iwan; Xu, Zhang B.; Collini, Michael D.; Miller, Chris P.; Dinh, Tam; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5021 - 5040
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: WO2006/64757 A1, 2006 ;
Location in patent: Page/Page column 115-116 ;
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / 0 - 20 °C
1.2: 13.2 g / tetrahydrofuran; hexane / 4 h / 0 - 20 °C
2.1: 100 percent / NaHCO3; Pd/C / ethyl acetate; ethanol / 20 h / 20 °C
View Scheme
参考文献
Malamas, Michael S.; Manas, Eric S.; McDevitt, Robert E.; Gunawan, Iwan; Xu, Zhang B.; Collini, Michael D.; Miller, Chris P.; Dinh, Tam; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5021 - 5040
反应条件
1.1: NaH / dimethylformamide / 0 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / 0 - 20 °C
2.2: 13.2 g / tetrahydrofuran; hexane / 4 h / 0 - 20 °C
3.1: 100 percent / NaHCO3; Pd/C / ethyl acetate; ethanol / 20 h / 20 °C
View Scheme
参考文献
Malamas, Michael S.; Manas, Eric S.; McDevitt, Robert E.; Gunawan, Iwan; Xu, Zhang B.; Collini, Michael D.; Miller, Chris P.; Dinh, Tam; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5021 - 5040
