1,3,5-三甲氧基苯合成路线 （共 273 条）
反应条件
pyridine; aluminium trichloride; tetreamethyl ammonium hydroxide
1.) Et2O, 21 deg C, 15 h, 2.) reflux, 34 h; Yield given. Multistep reaction;
参考文献
Liou; Shieh; Cheng; Won; Lin
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 9 p. 791 - 794
反应条件
acetonitrile; boron trifluoride diethyl etherate in tetrachloromethane
T=0 - 5°C;
参考文献
Ibata, Toshikazu; Yamamoto, Masahiko
Chemistry Letters, 1981 , p. 161 - 164
反应条件
boron trifluoride diethyl etherate in tetrachloromethane
T=0 - 5°C;
参考文献
Ibata, Toshikazu; Yamamoto, Masahiko
Chemistry Letters, 1981 , p. 161 - 164
反应条件
1.1: glacial acetic acid / 1 h
1.2: 37 percent / HBr; AcOH / 3 h / 70 °C
2.1: 63 percent / benzene / 24 h / Heating
3.1: BBr3 / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Li, Hengfeng; Homan, Edwin A.; Lampkins, Andrew J.; Ghiviriga, Ion; Castellano, Ronald K.
Organic Letters, 2005 , vol. 7, # 3 p. 443 - 446
反应条件
1: 85 percent / POCl3 / 40 - 50 °C
2: 82 percent / NH4OAc / Heating
View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
aluminium trichloride in carbon disulfide
4 h; Heating;
参考文献
Numata; Katsuno; Yamamoto; et al.
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 325 - 331
反应条件
1: AlCl3 / 1,2-dichloro-ethane
2: 68 percent / AlCl3 / CHCl3
3: 46 percent / morpholine
4: 86 percent / BBr3 / CH2Cl2
5: 32 percent / DDQ / tetrahydrofuran
6: 43 percent / Pyr*HCl / Heating
View Scheme
参考文献
Miller, Chris P.; Collini, Michael D.; Harris, Heather A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2399 - 2403
反应条件
AlCl3, aluminium chloride in diethyl ether
T=20°C; 8 h;
参考文献
Dai, Ming; Yuan, Xing; Kang, Jian; Zhu, Zhi-Jun; Yue, Rong-Cai; Yuan, Hu; Chen, Bing-Yang; Zhang, Wei-Dong; Liu, Run-Hui; Sun, Qing-Yan
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 159 - 166
反应条件
aluminium trichloride in diethyl ether
8 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Jiang, De-Jian; Hu, Gao-Yun; Jiang, Jun-Lin; Xiang, Hong-Lin; Deng, Han-Wu; Li, Yuan-Jian
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5171 - 5177
反应条件
tert.-butylhydroperoxide; methanesulfonic acid in decane; ethyl acetate
T=40°C; 6 h; Solvent;
参考文献
Schweitzer-Chaput, Bertrand; Sud, Abhishek; Pinter, Aron; Dehn, Stefanie; Schulze, Philipp; Klussmann, Martin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 50 p. 13228 - 13232
Angew. Chem., 2013 , vol. 125, # 50 p. 13470 - 13474,5
