1,3,5-三甲氧基苯合成路线 （共 273 条）
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 1 h / 0 °C / |Inert atmosphere
1.2: 48 h / 20 °C / |Inert atmosphere
2.1: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / |Inert atmosphere
2.2: 1.3 h / 0 - 20 °C
View Scheme
参考文献
Thevenin, Marion; Mouray, Elisabeth; Grellier, Philippe; Dubois, Joelle
European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2986 - 2992
反应条件
phloroglucinol trimethyl ether; trifluorormethanesulfonic acid
1.) room temperature, 2.5 h, 2.) diethyl ether, 19 h; Yield given. Multistep reaction;
参考文献
Booth, Brian L.; Noori, Ghazi F.M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2894 - 2900
反应条件
1: phloroglucinol trimethyl ether With n-butyllithium in hexane; cyclohexane
0.5 h; Heating;
2: prenyl bromide in hexane; cyclohexane
2 h; Heating;
参考文献
Gulacsi, Katalin; Litkei, Gyoergy; Antus, Sandor; Szantay, Csaba; Darko, Laszlo L.; Szelenyi, Judith; Hasko, Gyoergy; Vizi, Szilveszter E.
Archiv der Pharmazie, 2001 , vol. 334, # 2 p. 53 - 61
反应条件
1: phloroglucinol trimethyl ether With silver tetrafluoroborate; (4-ClPhO)3PAuCl in dichloromethane
0.0333333 h;
2: 3-methyl-1,2-butadiene in dichloromethane
T=20°C; 4 h;
参考文献
Tarselli, Michael A.; Liu, Ann; Gagne, Michel R.
Tetrahedron, 2009 , vol. 65, # 9 p. 1785 - 1789
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=0°C; 4 h;
参考文献
Araki, Shuki; Manabe, Shin-ichi; Butsugan, Yasuo
Chemistry Letters, 1982 , p. 797 - 800
反应条件
carbon monoxide in nitromethane
T=25°C; P=760 Torr; 4 h; Yield given. Yields of byproduct given;
参考文献
Dieter, Janice W.; Li, Zhong; Nicholas, Kenneth M.
Tetrahedron Letters, 1987 , vol. 28, # 45 p. 5415 - 5418
反应条件
1: I2, CF3CO2Ag / CHCl3 / Ambient temperature
2: 67 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 21 h / 80 °C
3: H2 / Raney Ni / methanol / 20 °C
4: 75 percent / TsOH*H2O / toluene / Heating
View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: 98 percent / ZnCl2
2: 96 percent / 50 percent aq. KOH / ethanol / 6 h / 20 °C
3: 91 percent / AlCl3 / 10 h / 20 °C
4: 74 percent / I2; pyridine / 8 h / Heating
5: 94 percent / K2CO3 / acetone / 8 h / Heating
View Scheme
参考文献
Lee, Yean-Jang; Wu, Tsao-Dong
Journal of the Chinese Chemical Society, 2001 , vol. 48, # 2 p. 201 - 206
反应条件
oxygen; palladium diacetate; trifluoroacetic acid in 1,2-dichloro-ethane
T=25°C; P=760.051 Torr; 5 h; Sealed tube; Catalytic behavior; Reagent/catalystSolventTimeTemperature; regioselective reaction;
参考文献
Yip, Kai-Tai; Nimje, Roshan Y.; Leskinen, Mikko V.; Pihko, Petri M.
Chemistry - A European Journal, 2012 , vol. 18, # 40 p. 12590 - 12594
反应条件
zinc(II) chloride in 1,2-dichloro-ethane
2 h; Heating;
参考文献
Kerr, Penelope J.; Pyke, Simon M.; Ward, A. David
Australian Journal of Chemistry, 2008 , vol. 61, # 5 p. 350 - 358
