N-(3-羟基苯基)乙酰胺合成路线 （共 86 条）
反应条件
1: 88 percent / K2CO3 / acetone / Heating 2: PhNMe2 / 6 h / Heating 3: 82 percent / K2CO3 / acetone / Heating 4: 81 percent / HCl / 2 h / Heating View Scheme
参考文献
Sakamuri; Kozikowski
Chemical Communications, 2001 , # 5 p. 475 - 476
反应条件
1: 74 percent / K2CO3 / acetone / 8 h / Heating 2: 98 percent / lithium diisopropylamide / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temperature, 2 h 3: 91 percent / KOH / methanol / 12 h / Heating View Scheme
参考文献
Morton; Slaunwhite
Journal of Biological Chemistry, 1949 , vol. 179, p. 259,264
反应条件
(i) NaOEt, EtOH, (ii) aq. HCl; Multistep reaction;
参考文献
Shadbolt; Sharpe; Brown; Ashford; Ross
Journal of medicinal chemistry, 1971 , vol. 14, # 9 p. 836 - 842
反应条件
1: NaOH-solution 2: hydrochloric acid View Scheme
参考文献
Boehringer Mannheim GmbH
Patent: US4769447 A1, 1988 ;
反应条件
1: potassium carbonate; acetone 2: aq.-ethanolic KOH-solution View Scheme
参考文献
El Ella; Saleh; Hassan; Hamdy; El-Araby; Abouzid
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 8 p. 360 - 366
反应条件
1: alkali 2: diluted hydrochloric acid View Scheme
参考文献
Reverdin; de Luc
Chemische Berichte, 1914 , vol. 47, p. 1544
Chemische Berichte, 1915 , vol. 48, p. 57
反应条件
2: AlCl3; CS2 3: aqueous HCl View Scheme
参考文献
Julia; Baillarge
Bulletin de la Societe Chimique de France, 1952 , p. 639
反应条件
1: 65 percent / NaOH / ethanol / 8 h / Heating 2: 64 percent / Na2CO3 / dimethylformamide / 24 h / 100 °C View Scheme
参考文献
Jaen, Juan C.; Wise, Lawrence D.; Heffener, Thomas G.; Pugsley, Thomas A.; Meltzer, Leonard T.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1621 - 1625
反应条件
1: (i) Na, EtOH, (ii) aq. NaOH 2: (i) aq. H2SO4, (ii) NaNO2, (iii) (heating) 3: ICl, NaCl, aq. NH3 View Scheme
参考文献
Pharmazie, , vol. 16, p. 389 - 395
反应条件
potassium carbonate in acetone
Heating;
参考文献
Sakamuri; Kozikowski
Chemical Communications, 2001 , # 5 p. 475 - 476
