N-(3-羟基苯基)乙酰胺合成路线 （共 86 条）
反应条件
1: potassium carbonate; potassium iodide / acetone / |Reflux
2: sodium hydroxide; water / ethanol / |Reflux
View Scheme
参考文献
El Ella; Saleh; Hassan; Hamdy; El-Araby; Abouzid
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 8 p. 360 - 366
反应条件
1.1: 63 percent / KOH / acetone / 5 h / 25 °C
2.1: 66 percent / aq. HCl / ethanol / 2 h / Heating
3.1: NaNO2; H2SO4 / H2O / -2 °C
3.2: CuSO4*9H2O / H2O / Heating
View Scheme
参考文献
Kremlev; Mushta; Moklyarchuk
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 8 p. 1125 - 1129
反应条件
sodium isopropanolate in isopropyl alcohol
Heating;
参考文献
Jaen, Juan C.; Wise, Lawrence D.; Heffener, Thomas G.; Pugsley, Thomas A.; Meltzer, Leonard T.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1621 - 1625
反应条件
1: 870 mg / K2CO3, KI, H2O / acetone / 96 h
2: N,N-diethylaniline / 2 h / Heating
View Scheme
参考文献
Yogo; Ito; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 2 p. 328 - 334
反应条件
1: phosphoryl chloride
2: hydrogen chloride; ethanol
3: copper (I)-bromide / Ueber das Diazoniumsalz
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参考文献
Rao; Sundaramurthy
Proceedings - Indian Academy of Sciences, Section A, 1956 , # 43 p. 149
反应条件
1: (i) K2CO3, acetone, (ii) aq. NaOH
2: (i) aq. H2SO4, (ii) NaNO2, (iii) aq. KI
View Scheme
参考文献
Cassebaum,H.
Pharmazie, 1960 , vol. 15, # 6 p. 310 - 316
反应条件
1: 870 mg / K2CO3, KI, H2O / acetone / 96 h
2: N,N-diethylaniline / 2 h / Heating
3: 49 percent / 6N HCl / ethanol / 2 h / Heating
View Scheme
参考文献
Yogo; Ito; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 2 p. 328 - 334
反应条件
1: 870 mg / K2CO3, KI, H2O / acetone / 96 h
2: N,N-diethylaniline / 2 h / Heating
3: 99 percent / 6N HCl / ethanol / 2 h / Heating
View Scheme
参考文献
Yogo; Ito; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 2 p. 328 - 334
反应条件
in sulfuric acid
T=20°C; Pechmann condensation; 10 h;
参考文献
Kele, Peter; Orbulescu, Jhony; Calhoun, Tiffany L; Gawley, Robert E; Leblanc, Roger M
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4413 - 4416
反应条件
1: glacial acetic acid; chlorine / 15 - 20 °C
2: KOH-solution
3: hydrochloric acid
4: Diazotization.Verkochen in schwefelsaurer Loesung und Behandeln des Reaktionsproduktes mit Dimethylsulfat und Kalilauge
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参考文献
Jacobs; Heidelberger; Rolf
Journal of the American Chemical Society, 1919 , vol. 41, p. 460
