3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
potassium carbonate; copper(II) oxide in pyridine T=150°C; 23 h;
参考文献
Archiv der Pharmazie, , vol. 316, # 7 p. 624 - 629
反应条件
potassium carbonate; copper(II) oxide in pyridine T=150°C; 17 h;
参考文献
Archiv der Pharmazie, , vol. 316, # 7 p. 624 - 629
参考文献
Schorygin; Isaguljanz; Below
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1930 , vol. 62, p. 2039,2043
Chemische Berichte, 1931 , vol. 64, p. 274,279 Anm. 12
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / |Reflux 2: ammonium acetate / |Heating 3: tin(IV) chloride / dichloromethane / -94 °C 4: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 5: silver nitrate / acetone; water / 3 h / |Reflux 6: acetic acid; zinc / 24 h 7: sodium cyanoborohydride / 1 h 8: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 9: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Zhmurov, Petr A.; Sukhorukov, Alexey Yu.; Chupakhin, Vladimir I.; Khomutova, Yulia V.; Ioffe, Sema L.; Tartakovsky, Vladimir A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8082 - 8091
反应条件
sodium hydroxide; nickel monoaluminide T=90°C;
参考文献
Journal of Organic Chemistry, , vol. 9, p. 1,5
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / |Reflux 2: ammonium acetate / |Heating 3: tin(IV) chloride / dichloromethane / -94 °C 4: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 5: silver nitrate / acetone; water / 3 h / |Reflux 6: acetic acid; zinc / 24 h 7: sodium cyanoborohydride / 1 h 8: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 9: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Zhmurov, Petr A.; Sukhorukov, Alexey Yu.; Chupakhin, Vladimir I.; Khomutova, Yulia V.; Ioffe, Sema L.; Tartakovsky, Vladimir A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8082 - 8091
反应条件
1: 95 percent / DMAP, Et3N / tetrahydrofuran; diethyl ether / 14 h / Ambient temperature 2: 87.5 percent / m-chloroperbenzoic acid / CH2Cl2 / 2.5 h / Heating 3: Cs2CO3 / dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Aihara, Kazuhiro; Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 11 p. 2165 - 2170
反应条件
1: 95 percent / anhydrous potassium carbonate / dimethylformamide / 2 h / 100 °C 2: 96 percent / sodium borohydride / ethanol / 1 h / Ambient temperature 3: 95 percent / pyridine / 0.5 h / Ambient temperature; addition of reagent at ice-bath cooling 4: 94 percent / sodium acetate, bromine / acetic acid / 1 h / Ambient temperature; addition of bromine at 15 deg C 5: 94 percent / potassium hydroxide / methanol / 0.5 h / Ambient temperature 6: 79 percent / potassium permanganate / acetone; H2O / Heating 7: oxalyl chloride, pyridine / benzene / 1 h / ice-bath cooling 8: 65 percent / triethylamine / benzene / ice-bath cooling 9: 96 percent / 10percent hydrochlorid acid / ethanol / 0.5 h / Heating View Scheme
参考文献
Vlahov, Radoslav; Krikorian, Dikran; Spassov, Grigor; Chinova, Maja; Vlahov, Ioncho; et al.
Tetrahedron, 1989 , vol. 45, # 11 p. 3329 - 3346
反应条件
1: 88 percent / sodium formate; formic acid; hydroxylamine sulfate / 8 h / 85 °C 2: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 3: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 4: 75 percent / sodium dithionite / H2O / 20 - 50 °C 5: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
sodium hydroxide; dipotassium peroxodisulfate
参考文献
Daly,J. et al.
Journal of the American Chemical Society, 1961 , vol. 83, p. 4787 - 4792
