3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: 97 percent / K2CO3 / dimethylformamide / 100 °C 2: 90 percent / NH4OAc; acetic acid / 2 h / 90 °C 3: 94 percent / 1,1-bis(3aS,8aR-dihydroindeno[1,2-d]oxazol-2-yl)cyclopropane; Mg(OTf)2*4H2O; N-methylmorpholine / 4A molecular sieves / CHCl3 / 20 °C 4: H2; H2PO4 / Raney-Ni / tetrahydrofuran / 50 - 60 °C / 2068.65 Torr 5: aq. NaOH / ethanol; tetrahydrofuran 6: TsOH / isopropyl acetate / Heating View Scheme
参考文献
Barnes, David M.; Wittenberger, Steven J.; Zhang, Ji; Ji, Jianguo; Fickes, Michael G.; Fitzgerald, Michael A.; King, Steven A.; Morton, Howard E.; Plagge, Frederick A.; Preskill, Margo; Wagaw, Seble H.
Journal of the American Chemical Society, 2002 , vol. 124, # 44 p. 13097 - 13105
反应条件
1: 1.) NaOEt / 1.) EtOH, 2.) reflux, 2 h 2: 100 percent / NaBH4 / H2O; ethanol / 1 h / 20 - 25 °C 3: 97 percent / SOCl2, pyridine / diethyl ether / 0.5 h / below 5 deg C 4: 92 percent / KI, urea / acetone / 6 h / Heating 5: H2 / 10percent Pd/C / acetone / 1 h / Ambient temperature 6: 10percent aq. NaOH / 1 h / 0 °C View Scheme
参考文献
Bhandari, Prabha; Crombie, Leslie; Daniels, Peter; Holden, Ian; Bruggen, Nicholas Van; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 7 p. 839 - 850
反应条件
1: 3-hydroxy-4-methoxy-benzaldehyde; acetic anhydride 2: With 3-chloro-benzenecarboperoxoic acid in dichloromethane 3: With sodium hydrogencarbonate in ethanol
参考文献
Zhang, Qingzhi; Botting, Nigel P.
Tetrahedron, 2004 , vol. 60, # 52 p. 12211 - 12216
反应条件
1: 95 percent / DMAP, Et3N / tetrahydrofuran; diethyl ether / 14 h / Ambient temperature 2: 87.5 percent / m-chloroperbenzoic acid / CH2Cl2 / 2.5 h / Heating View Scheme
参考文献
Aihara, Kazuhiro; Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 11 p. 2165 - 2170
反应条件
1: 98 percent / K2CO3 / acetonitrile 2: NaBH4 / ethanol 3: PBr3 / CH2Cl2 4: 76 percent / LiHMDS / tetrahydrofuran 5: 81 percent / LiOH; H2O2 6: 95 percent / LAH / tetrahydrofuran 7: 97 percent / PPh3; NBS / CH2Cl2 8: 68 percent / n-BuLi View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
参考文献
Speicher, Andreas; Kolz, Juergen; Sambanje, Rufino Paulino
Synthesis, 2002 , # 17 p. 2503 - 2512
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0 - 20°C; sealed tubeInert atmosphere;
参考文献
Naidu, Ajay B.; Ganapathy; Sekar, Govindasamy
Synthesis, 2010 , # 20 art. no. Z15310SS, p. 3509 - 3519
参考文献
Kraouti; Caujolle; Labidalle; Payard; Bories; Loiseau; Gayral
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 979 - 982
反应条件
anschliessend mit einer Loesung vom 1 Mol Acetanhydrid in Aether bei 0grad;
参考文献
Raiford; Ravely
Journal of Organic Chemistry, 1940 , vol. 5, p. 204,208
参考文献
Bersch
Archiv der Pharmazie (Weinheim, Germany), 1939 , vol. 277, p. 271,281
