3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
nitric acid; acetic acid T=-5 - 30°C; 12 h;
参考文献
CIPLA LIMITED; CURTIS, Philip, Anthony
Patent: WO2008/125867 A2, 2008 ;
Location in patent: Page/Page column 25 ;
反应条件
hydrogenchloride; sodium nitrate; sodium chloride; sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
Japan Tobacco Inc.
Patent: US6509352 B1, 2003 ;
反应条件
1.1: 92 percent / triethylamine / dimethylformamide / 20 °C 2.1: n-BuLi / tetrahydrofuran / 3 h / -78 °C 2.2: tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5767 - 5772
反应条件
1.1: potassium carbonate / ethanol / 20 h / 20 °C / Inert atmosphere 2.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2.5 h / -10 °C / Inert atmosphere 3.1: sodium tetrahydroborate; diphenyl diselenide; sodium hydroxide / ethanol / 18 h / 40 °C 4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere 5.1: sodium hydroxide / chloroform / 0 - 20 °C 6.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere 6.2: 20 °C / Inert atmosphere; Cooling with ice 7.1: palladium 10 on activated carbon; hydrogen; acetic acid / methanol / 16 h 8.1: berberine bridge enzyme; tris(hydroxymethyl)methylamine hydrochloride; magnesium chloride / toluene / 24 h / 40 °C / pH 9 / Darkness; Enzymatic reaction View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
nitronium tetrafluoroborate in dichloromethane T=-20°C; 24 h; Inert atmosphere;
参考文献
Turkman, Nashaat; Shavrin, Aleksander; Ivanov, Roman A.; Rabinovich, Brian; Volgin, Andrei; Gelovani, Juri G.; Alauddin, Mian M.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5698 - 5707
反应条件
sulfuric acid; nitric acid in water; acetic acid
参考文献
Japan Tobacco Inc.
Patent: US6017919 A1, 2000 ;
反应条件
AcONO2; silica gel in chloroform T=-20 - 20°C; Nitration;
参考文献
Tetrahedron, , vol. 55, # 22 p. 6733 - 6738
反应条件
1: potassium carbonate / N,N-dimethyl-formamide 2: Ba(OH)2·8H2O / methanol / 50 °C / |Inert atmosphere 3: boron trichloride / dichloromethane; hexane / 3.5 h / -78 - 0 °C / |Inert atmosphere View Scheme
参考文献
Amslinger, Sabine; Al-Rifai, Nafisah; Winter, Katrin; Woermann, Kilian; Scholz, Rebekka; Baumeister, Paul; Wild, Martin
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 4 p. 549 - 554
反应条件
1: sodium hydroxide / water; methanol / 4 h / 20 °C 2: sodium periodate / dimethyl sulfoxide / 8 h / 100 °C / |Inert atmosphere 3: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Ribeiro, Daniela; Freitas, Marisa; Tome, Sara M.; Silva, Artur M. S.; Porto, Graca; Fernandes, Eduarda
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 280 - 292
反应条件
1: Cl2 / CH2Cl2 2: BBr3 4: ZnI2 5: LiAlH4 6: H2 / Pd/C View Scheme
参考文献
Squier; Van der Schyf; Oliver; Venter
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 3 p. 457 - 460
