3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 5 h
2: toluene-4-sulfonic acid / toluene / 23 h / |Reflux
3: lithium; chloro-diphenylphosphine / tetrahydrofuran / 2 h
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参考文献
PFIZER INC.; Brodney, Michael Aaron; Efremov, Ivan Viktorovich; Helal, Christopher John; O'Neill, Brian Thomas
Patent: US2013/150376 A1, 2013 ;
反应条件
1: potassium carbonate / ethanol / 50 °C
2: sodium hydride / tetrahydrofuran / 0 °C
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参考文献
Park, Ju-Eun; Lee, Juyeun; Seo, Seung-Yong; Shin, Dongyun
Tetrahedron Letters, 2014 , vol. 55, # 4 p. 818 - 820
反应条件
antimony trichloride
T=20°C; 0.0833333 h;
参考文献
Bhattacharya, Asish K.; Mujahid, Mohammad; Natu, Arvind A.
Synthetic Communications, 2008 , vol. 38, # 1 p. 128 - 134
反应条件
1: methanol; aqueous formaldehyde; aqueous KOH
2: K2CO3; acetone
3: 230 °C
View Scheme
参考文献
Schwarz; Capek
Monatshefte fuer Chemie, 1953 , vol. 84, p. 595,604
反应条件
1: 36 percent / Br2
2: 80 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: NaBH4 / aq. ethanol / 1 h / 25 °C
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参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1.2: MCPBA / CH2Cl2
1.3: aq. NaHCO3 / ethanol
2.1: BF3*Et2O / 70 °C
View Scheme
参考文献
Zhang, Qingzhi; Botting, Nigel P.
Tetrahedron, 2004 , vol. 60, # 52 p. 12211 - 12216
参考文献
Vansdadia; Roda; Parekh
Journal of the Indian Chemical Society, 1989 , vol. 66, # 2 p. 110 - 112
反应条件
sodium hydrogensulfite
anschliessendes Behandeln mit wss. Kaliumcyanid-Loesung;
参考文献
Hahn; Tulus
Chemische Berichte, 1941 , vol. 74, p. 500,517
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Hahn; Stiehl
Chemische Berichte, 1938 , vol. 71, p. 2154,2161
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Hahn; Stiehl; Schulz
Chemische Berichte, 1939 , vol. 72, p. 1291,1296
反应条件
1: 36 percent / Br2
2: 80 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: NaBH4 / aq. ethanol / 1 h / 25 °C
4: 12 N aq. HCl
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
4: 97 percent / 12N aq. HCl
5: 96 percent / dimethylsulfoxide / 1.25 h
6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
7: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
