3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: PPh3 / CH2Cl2 / 2 h
2: BuLi / hexane; tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Pagliai, Francesca; Pirali, Tracey; Del Grosso, Erika; Di Brisco, Riccardo; Tron, Gian Cesare; Sorba, Giovanni; Genazzani, Armando A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 467 - 470
反应条件
1: 88 percent / potassium carbonate / dimethylformamide
3: Jones reagent
View Scheme
参考文献
Ishii, Hisashi; Chen, Ih-Sheng; Ishikawa, Tsutomu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 671 - 676
反应条件
1: 80 percent / potassium carbonate / acetone / 5 h / Heating
2: 83 percent / sodium borohydride / ethanol / 0.5 h
3: 88 percent / PBr3 / benzene / 0.5 h / 5 °C
4: 50 percent / n-butyl lithium / tetrahydrofuran / 3 h / -30 °C
5: mercuric chloride / methanol; tetrahydrofuran / 24 h / 130 °C
6: trifluoroacetic acid / 3 h / Ambient temperature
View Scheme
参考文献
Annapurna, G. S.; Deshpande, V. H.
Synthetic Communications, 1983 , vol. 13, # 13 p. 1075 - 1082
反应条件
1.1: 93 percent / K2CO3 / acetonitrile / 19 h / Heating
2.1: 72 percent / NaOMe / methanol / 1.5 h / Heating
3.1: 96 percent / NaBH4 / methanol / 1 h / 20 °C
4.1: 100 percent / Me3SiBr / 0.17 h / 20 °C
5.1: LiHMDS / tetrahydrofuran / 1.25 h / -70 °C
5.2: 86 percent / tetrahydrofuran / 18 h / 0 °C
6.1: 94 percent / H2O2; LiOH / tetrahydrofuran; H2O / 3 h / 20 °C
7.1: NaBH4 / tetrahydrofuran / 0.75 h / 20 °C
7.2: 90 percent / I2 / tetrahydrofuran / 96 h / 20 °C
8.1: 97 percent / NBS; Ph3P / CH2Cl2 / 18 h / 20 °C
9.1: BuLi / hexane / 0.5 h / -75 °C
9.2: 91 percent / tetrahydrofuran / 20 h / -75 - -20 °C
10.1: 90 percent / 1N HCl / acetonitrile / 1.5 h / 20 °C
11.1: 82 percent / Et3N / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
sodium acetate in acetic acid
8 h; Heating;
参考文献
Agarwal, Jagdish C.; Gupta, Y. K.; Bhargava, K. P.; Shanker, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 8 p. 714 - 716
反应条件
in N,N-dimethyl-formamide
参考文献
Ben, Ines; Castedo, Luis; Saa, Jose M.; Seijas, Julio A.; Suau, Rafael; Tojo, Gabriel
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2236 - 2240
反应条件
piperidine in ethanol
Heating;
参考文献
Gazit, Aviv; Yaish, Pnina; Gilon, Chaim; Levitzki, Alexander
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2344 - 2352
反应条件
1: aq. NaOH, (NH4)2S2O8
2: K2CO3
View Scheme
参考文献
Daly,J. et al.
Journal of the American Chemical Society, 1961 , vol. 83, p. 4787 - 4792
参考文献
Ploypradith, Poonsakdi; Petchmanee, Thaninee; Sahakitpichan, Poolsak; Litvinas, Nichole D.; Ruchirawat, Somsak
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9440 - 9448
反应条件
1: potassium carbonate / ethanol / 20 h / 20 °C / Inert atmosphere
2: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2.5 h / -10 °C / Inert atmosphere
View Scheme
参考文献
Resch, Verena; Lechner, Horst; Schrittwieser, Joerg H.; Wallner, Silvia; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 41 p. 13173 - 13179
