3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: potassium carbonate / 60 °C
2: potassium permanganate / acetone / |Reflux
3: thionyl chloride / |Reflux
4: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C
5: acetic acid; iron / methanol
6: ethanol / |Reflux
7: trichlorophosphate; triethylamine / toluene / |Reflux
8: isopropyl alcohol / |Reflux
View Scheme
参考文献
Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388
反应条件
1: 85 percent / tetrahydrofuran / 5 - 20 °C
2: DDQ / dioxane / 1 h
3: 19.88 g / Et3N / CH2Cl2
View Scheme
参考文献
Waters, Marjorie S.; Onofiok, Ekama; Tellers, David M.; Chilenski, Jennifer R.; Song, Zhiguo Jake
Synthesis, 2006 , # 20 p. 3389 - 3396
反应条件
1: 85 percent / tetrahydrofuran / 5 - 20 °C
2: DDQ / dioxane / 1 h
3: 19.88 g / Et3N / CH2Cl2
4: phenyltrimethylammonium tribromide / 1,2-dimethoxy-ethane; CH2Cl2 / 1 h / 40 - 45 °C
5: 18.43 g / Et3N / ethyl acetate / 1.5 h / 20 °C
6: 82 percent / PhPOCl2 / acetonitrile / 2.5 h / Heating
7: 96 percent / aq. NaOH / ethanol / 2 h / 65 - 70 °C
View Scheme
参考文献
Waters, Marjorie S.; Onofiok, Ekama; Tellers, David M.; Chilenski, Jennifer R.; Song, Zhiguo Jake
Synthesis, 2006 , # 20 p. 3389 - 3396
反应条件
potassium carbonate
T=60°C;
参考文献
Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388
反应条件
1: pyridine / Heating
2: p-toluenesulfonic acid / toluene / Heating
3: aq. Na3PO4 / Heating
View Scheme
参考文献
Bratt, Katarina; Sunnerheim, Kerstin; Bryngelsson, Susanne; Fagerlund, Amelie; Engman, Lars; Andersson, Rolf E.; Dimberg, Lena H.
Journal of Agricultural and Food Chemistry, 2003 , vol. 51, # 3 p. 594 - 600
反应条件
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: potassium carbonate / 60 °C
2: potassium permanganate / acetone / |Reflux
3: thionyl chloride / |Reflux
4: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C
5: acetic acid; iron / methanol
6: ethanol / |Reflux
7: trichlorophosphate; triethylamine / toluene / |Reflux
View Scheme
参考文献
Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388
反应条件
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
4: 97 percent / 12N aq. HCl
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
acetic acid in ethanol
Heating;
参考文献
Pande, Kalpana; Tandon, Manju; Bhalla, T. N.; Barthwal, J. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1133 - 1135
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C;
参考文献
EPR PHARMACEUTICALS PVT.LTD
Patent: US2010/152491 A1, 2010 ;
Location in patent: Page/Page column 28 ;
