3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: 87 percent / K2CO3 / acetone / 8 h / Heating
2: 92 percent / 3 h / 180 °C
3: K2CO3 / acetone / 8 h / Heating
4: H2O2; H(1+) / methanol / 1.5 h / 20 °C
View Scheme
参考文献
Wang, Eng-Chi; Hsu, Ming-Kun; Lin, Yu-Li; Huang, Keng-Shiang
Heterocycles, 2002 , vol. 57, # 11 p. 1997 - 2010
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere
2: potassium hydroxide / ethanol / |Cooling with ice
3: iodine / pyridine / 24 h / 80 °C
4: boron tribromide / dichloromethane / 72 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ndoile, Monica M.; Van Heerden, Fanie R.
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1346 - 1351
反应条件
1: NaBH4
2: (KO3S)2NO, aq. KH2PO4
View Scheme
参考文献
Danishefsky; Schuda; Kato
Journal of Organic Chemistry, 1976 , vol. 41, # 7 p. 1081 - 1088
反应条件
1: nitronium tetrafluoroborate / dichloromethane / 24 h / -20 °C / Inert atmosphere
2: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 25 h / 20 - 80 °C / Inert atmosphere
View Scheme
参考文献
Turkman, Nashaat; Shavrin, Aleksander; Ivanov, Roman A.; Rabinovich, Brian; Volgin, Andrei; Gelovani, Juri G.; Alauddin, Mian M.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5698 - 5707
反应条件
1: 92 percent / Br2; AcONa; Fe / acetic acid / 5 h
2: 66 percent / KOH / methanol / 16 h / Heating
View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8725 - 8728
反应条件
1: 89 percent / NaHCO3; KI / acetonitrile / 10 h / Heating
2: 96 percent / NaBH4 / methanol / 2 h / 20 °C
3: 85 percent / PBr3; pyridine / diethyl ether / 2 h / Heating
View Scheme
参考文献
Meyers, A. I.; Guiles, Joseph
Heterocycles, 1989 , vol. 28, # 1 p. 295 - 301
反应条件
Claisen-Schmidt condensation;
参考文献
Todorova, Iva T.; Batovska, Daniela I.; Stamboliyska, Bistra A.; Parushev, Stoyan P.
Journal of the Serbian Chemical Society, 2011 , vol. 76, # 4 p. 491 - 497
反应条件
1: 92 percent / K2CO3 / acetone / 8 h / Heating
2: 95 percent / decahydronaphthalene / 5 h / 180 °C
3: 88 percent / K2CO3 / acetone / 8 h / Heating
4: 96 percent / tetrahydrofuran / 2 h / 20 °C
5: 86 percent / [Ph-CH=RuCl2(PCy3)2] / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Huang, Keng-Shiang; Wang, Eng-Chi; Chen, Hsing-Ming
Journal of the Chinese Chemical Society, 2004 , vol. 51, # 3 p. 585 - 605
反应条件
1: 35 percent / Cu, K2CO3, pyridine / 1.5 h / 140 - 150 °C
2: 99 percent / LiAlH4 / tetrahydrofuran / 0.25 h / 0 °C
View Scheme
参考文献
Knabe; Weirich
Archiv der Pharmazie, 1983 , vol. 316, # 5 p. 445 - 449
反应条件
potassium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide)
T=65 - 85°C; 25 h;
参考文献
ELBION AG
Patent: WO2004/806 A1, 2003 ;
Location in patent: Page 24 ;
WO 2004/000806 A1
