3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
toluene-4-sulfonic acid in dichloromethane
参考文献
Inayama,S. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 433 - 436
反应条件
(i) Et3N, EtOH, (ii) H2, Pd-C; Multistep reaction;
参考文献
Yamato; Hashigaki; Uenishi; Yamakawa; Sato
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3101 - 3105
反应条件
1: diethyl ether / 3 h / Heating
2: hydrogen / Pd-C
View Scheme
参考文献
Arnarp; Bielawski; Dahlin; Dahlman; Enzell; Pettersson
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1989 , vol. 43, # 1 p. 44 - 50
反应条件
1.1: potassium carbonate / ethanol / 0.5 h / 20 °C
1.2: 5 h / 100 °C
2.1: nitric acid / dichloromethane / 1 h / 0 - 20 °C
View Scheme
参考文献
Li, Wen-Yan; Xiong, Xu-Qiong; Zhao, Dong-Mei; Shi, Yu-Fang; Yang, Zhi-Heng; Yu, Chao; Fan, Pei-Wei; Cheng, Mao-Sheng; Shen, Jing-Kang
Molecules, 2012 , vol. 17, # 5 p. 5497 - 5507
反应条件
1: K2CO3, KI / dimethylformamide / 21 h / 65 °C
2: sulfamic acid, aq. AcOH, aq. NaClO2 / 1 h / Ambient temperature
View Scheme
参考文献
Ashton, Michael J.; Cook, David C.; Fenton, Garry; Karlsson, Jan-Anders; Palfreyman, Malcolm N.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1696 - 1703
反应条件
oxygen; CoCl2 in 1,2-dichloro-ethane
T=25°C;
参考文献
Bhatia, Beena; Iqbal, Javed
Tetrahedron Letters, 1992 , vol. 33, # 51 p. 7961 - 7964
反应条件
1: aqueous KOH; diethyl ether / 0 °C
2: iodine; sodium acetate; acetic acid; bromine
View Scheme
参考文献
Raiford; Ravely
Journal of Organic Chemistry, 1940 , vol. 5, p. 204,208
反应条件
1: formic acid; hydroxylamine hydrochloride; sodium formate / 3 h / 125 °C
2: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Kumar, Dalip; Patel, Gautam; Vijayakrishnan, Lalitha; Dastidar, Sunanda G.; Ray, Abhijit
Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 810 - 818
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere
2.2: 20 °C / Cooling with salt-ice; Inert atmosphere
3.1: hydrogenchloride; water / diethyl ether / 0.5 h / 20 °C
3.2: pH 12 / Cooling with ice
4.1: methanol / 8 h / 20 °C / Inert atmosphere; Reflux
5.1: sodium hydroxide / dichloromethane; water / pH 11 / Cooling with ice
View Scheme
参考文献
Tianjin Hemay Bio-Tech Co., Ltd.; Tianjin Michele Sci-Tech Development Co., Ltd.
Patent: EP2431371 A1, 2012 ;
反应条件
1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / 20 °C
2: sodium hydroxide / methanol / 3 h / 20 °C
3: hydrogenchloride / 4 h / 20 °C
View Scheme
参考文献
Leow, Pay-Chin; Bahety, Priti; Boon, Choon Pei; Lee, Chong Yew; Tan, Kheng Lin; Yang, Tianming; Ee, Pui-Lai Rachel
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 67 - 80
