3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: 84 percent / pyridinium p-toluenesulfonate / benzene / Heating 2: 90 percent / potassium carbonate / dimethylformamide / 19 h / 155 °C 3: 92 percent / sodium borohydride / methanol / 1 h / 0 °C 4: 87 percent / triphenylphosphine; carbon tetrabromide / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Kodama; Shiobara; Sumitomo; Matsumura; Tsukamoto; Harada
Journal of Organic Chemistry, 1988 , vol. 53, # 1 p. 72 - 77
反应条件
1: sodium tetrahydroborate / methanol / 2 h / 20 °C 2: phosphorus tribromide / diethyl ether / 0.5 h / 0 °C View Scheme
参考文献
Kamal, Ahmed; Hussaini, Syed Mohammed Ali; Faazil, Shaikh; Poornachandra; Narender Reddy; Kumar, C. Ganesh; Rajput, Vikrant Singh; Rani, Chitra; Sharma, Rashmi; Khan, Inshad Ali; Jagadeesh Babu
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6842 - 6846
反应条件
1: in toluene; butan-1-ol 4 h; Heating / reflux; 2: With sodium tetrahydroborate in methanol T=0°C; 4 h;
参考文献
Sanochemia Pharmazeutica
Patent: US6369238 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
1: methanol / 1.) molecular sieves, r.t., overnight 2: sodium borohydride / methanol / 3 h / Ambient temperature View Scheme
参考文献
Szewczyk; Lewin; Carroll
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1809 - 1811
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
formic acid; hydroxylamine hydrochloride; sodium formate T=85°C; 4 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28939 A1, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
1: in formic acid T=85°C; 2: With hydroxylammonium sulphate in formic acid T=85°C; 5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/24703 A1, 2004 ;
Location in patent: Page 14 ;
WO 2004/024703 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=18°C; 42 h;
参考文献
Kimura, Shinya; Pangkruang, Waree; Yokoya, Masashi; Honda, Amane; Puthongking, Ploenthip; Suwanborirux, Khanit; Saito, Naoki
Heterocycles, 2014 , vol. 88, # 1 p. 363 - 375
反应条件
potassium carbonate in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Lawrence, Nicholas J.; Muhammad, Faiz
Tetrahedron, 1998 , vol. 54, # 50 p. 15345 - 15360
反应条件
potassium carbonate in N-methyl-acetamide; ethyl acetate
参考文献
Rhone-Poulenc Rorer Limited
Patent: US5679696 A1, 1997 ;
