1: 3-phenyl-2-propenoic acid With triethylamine; methyl chloroformate in dichloromethane
T=20°C; 2 h; Cooling with ice;
2: diethylamine in dichloromethane
T=20°C;
1: PCl5
2: 100 °C / Ueberfuehrung des entstandenen Cinnamoylameisensaeurenitrils in Cinnamoylameisensaeureamid durch Behandlung mit Salzsaeure und Verseifen des Amids mit verd. Kalilauge
View Scheme
参考文献
Claisen; Antweiler
Chemische Berichte, 1880 , vol. 13, p. 2124
1: diethyl ether / 20 °C
2: hydrogenchloride / water
View Scheme
参考文献
Cheng, Kejun; Lee, Yong Sok; Rothman, Richard B.; Dersch, Christina M.; Bittman, Ross W.; Jacobson, Arthur E.; Rice, Kenner C.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 957 - 969
Bargellini; Marantonio
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1908 , vol. <5> 17 II, p. 124
Gazzetta Chimica Italiana, 1908 , vol. 38 II, p. 521
