反应条件
1: trimethylsilylacetylene With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 2.16667 h;
2: With N,N,N',N',N'',N''-hexamethylphosphoric triamide in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
3: ethyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
SERAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; GOVEK, Steven, P.; KAHRAMAN, Mehmet; JULIEN, Jackaline, D.; NAGASAWA, Johnny, Y.; DOUGLAS, Karensa, L.; BONNEFOUS, Celine; LAI, Andiliy, G.
Patent: WO2013/142266 A1, 2013 ;
Location in patent: Paragraph 00511 ;
