4-羟基-5-嘧啶乙酸乙酯合成路线 （共 4 条）
反应条件
water; Raney nickel T=20°C; 90 h; Reflux;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 133 ;
反应条件
1.1: sodium / diethyl ether / 17 h / 0 - 20 °C / Inert atmosphere 2.1: sodium ethanolate / ethanol / 17 h / 20 °C / Inert atmosphere; Reflux 2.2: 0 °C 3.1: water / Raney nickel / 90 h / 20 °C / Reflux View Scheme
参考文献
WO2012/110773 A1, ;
WO 2012/110773 A1
反应条件
1.1: sodium ethanolate / ethanol / 17 h / 20 °C / Inert atmosphere; Reflux 1.2: 0 °C 2.1: water / Raney nickel / 90 h / 20 °C / Reflux View Scheme
参考文献
WO2012/110773 A1, ;
WO 2012/110773 A1
反应条件
trichlorophosphate 0.0833333 h; Inert atmosphereReflux;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 134 ;
