4-甲基-2-羟基嘧啶-5-羧酸乙酯合成路线 （共 15 条）
反应条件
pyridinium chlorochromate in dichloromethane T=20°C; 20 h;
参考文献
Singh, Kamaljit; Singh, Kawaljit
Australian Journal of Chemistry, 2008 , vol. 61, # 11 p. 910 - 913
反应条件
sodium hydride in tetrahydrofuran T=20°C; 1.6 h; Cooling with ice;
参考文献
Fesenko, Anastasia A.; Solovyev, Pavel A.; Shutalev, Anatoly D.
Tetrahedron, 2010 , vol. 66, # 4 p. 940 - 946
反应条件
1: ammonium chloride / 3 h / 100 °C 2: nitric acid / 0.5 h / 0 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 66, p. 314 - 323
反应条件
1: trichlorophosphate / 0.5 h / 105 °C 2: ethanol / 80 °C View Scheme
参考文献
Singh, Kamaljit; Singh, Kawaljit; Wan, Baojie; Franzblau, Scott; Chibale, Kelly; Balzarini, Jan
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2290 - 2294
反应条件
iodine; magnesium in methanol T=50°C; 30 h; chemoselective reaction;
参考文献
Singh, Kamaljit; Singh, Kawaljit
Tetrahedron Letters, 2009 , vol. 50, # 19 p. 2219 - 2221
反应条件
in butan-1-ol 9 h; Heating;
参考文献
Bulletin de la Societe Chimique de France, , # 2 p. 318 - 324
反应条件
1: trichlorophosphate / 0.5 h / 105 °C 2: ammonia / tetrahydrofuran / 0.75 h / 20 °C View Scheme
参考文献
Singh, Kamaljit; Singh, Kawaljit; Wan, Baojie; Franzblau, Scott; Chibale, Kelly; Balzarini, Jan
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2290 - 2294
反应条件
1: bromobenzene With magnesium in diethyl ether Grignard reaction; Inert atmosphere; 2: 6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester in tetrahydrofuran; diethyl ether T=-78°C; Grignard reaction; Inert atmosphere; chemoselective reaction;
参考文献
European Journal of Organic Chemistry, , # 19 p. 3258 - 3264
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Tetrahedron Letters, , vol. 48, # 8 p. 1349 - 1352
反应条件
trichlorophosphate T=105°C; 0.5 h;
参考文献
Singh, Kamaljit; Singh, Kawaljit; Wan, Baojie; Franzblau, Scott; Chibale, Kelly; Balzarini, Jan
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2290 - 2294
