7-硝基-2,3-二氢-苯并[1,4]二噁英-6-胺合成路线 （共 12 条）
反应条件
1: hydrogen / palladium 10 on activated carbon / methanol / 18 h 2: methanol / 5 h View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: EP2532665 A1, 2012 ;
反应条件
sulfuric acid; copper(I) bromide Diazotization;
参考文献
Journal of the Chemical Society, , p. 18,21
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 24 h; Product distribution; Further Variations:ReagentsSolventsTemperaturesCatalystsreaction times;
参考文献
Mateu; Capilla; Harrak; Pujol
Tetrahedron, 2002 , vol. 58, # 26 p. 5241 - 5250
反应条件
sulfuric acid
6 h; Reflux;
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: EP2532665 A1, 2012 ;
Location in patent: Page/Page column 30 ;
反应条件
iron; acetic acid
T=20°C; 0.5 h; Heating / reflux;
参考文献
Shimojo, Masato; Taniguchi, Kana
Patent: US2003/236260 A1, 2003 ;
Location in patent: Page 72 ;
US 20030236260 A1
反应条件
iron; acetic acid
T=90 - 100°C; 22 h;
参考文献
Mateu; Capilla; Harrak; Pujol
Tetrahedron, 2002 , vol. 58, # 26 p. 5241 - 5250
反应条件
nitric acid; acetic acid
T=20°C; 3 h;
参考文献
Mateu; Capilla; Harrak; Pujol
Tetrahedron, 2002 , vol. 58, # 26 p. 5241 - 5250
参考文献
Audoly, Laurent; Okumura, Takako; Shimojo, Masato
Patent: US2002/77329 A1, 2002 ;
US 20020077329 A1
反应条件
1: acetic acid; nitric acid
2: aq.-ethanolic hydrochloric acid
View Scheme
参考文献
Heertjes; Revallier
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 262,267
Full Text Show Details
Lott et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3621
反应条件
1: 54 percent / 2 h / 170 °C
2: 75 percent / Fe; AcOH / 22 h / 90 - 100 °C
View Scheme
参考文献
Mateu; Capilla; Harrak; Pujol
Tetrahedron, 2002 , vol. 58, # 26 p. 5241 - 5250
