1,3-二羟基丙酮二聚体合成路线 （共 44 条）
反应条件
sodium cyanoborohydride; ammonium chloride; acetic acid in methanol T=20°C;
参考文献
Jie, Yuanping; Livant, Peter; Li, Hui; Yang, Minmin; Zhu, Wei; Cammarata, Vince; Almond, Philip; Sullens, Tyler; Qin, Yu; Bakker, Eric
Journal of Organic Chemistry, 2010 , vol. 75, # 13 p. 4472 - 4479
反应条件
ammonium hydroxide; ammonium chloride T=80°C; 0.5 h;
参考文献
Thurkauf, Andrew; Hutchison, Alan; Peterson, John; Cornfield, Linda; Meade, Robin; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2251 - 2255
反应条件
bei mehrjaehrigem Aufbewahren eines Handelspraeparats unter Ausschluss von Licht und Luft; Prod.5: Milchsaeure;
参考文献
Sanna
Rend.Fac.Sci.Cagliari, 1946 , vol. 16, p. 249
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20 - 30°C;
参考文献
BTG INTERNATIONAL LIMITED
Patent: WO2005/18632 A1, 2005 ;
Location in patent: Page/Page column 28-30; 37-38 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C;
参考文献
BTG INTERNATIONAL LIMITED
Patent: WO2005/18632 A1, 2005 ;
Location in patent: Page/Page column 40 - 41 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20 - 40°C; 2 h;
参考文献
BTG INTERNATIONAL LIMITED
Patent: WO2005/18632 A1, 2005 ;
Location in patent: Page/Page column 34 ;
反应条件
Lipase PS in 1,4-dioxane T=30°C; 48 h;
参考文献
Tsujigami, Toshikuni; Sugai, Takeshi; Ohta, Hiromichi
Tetrahedron Asymmetry, 2001 , vol. 12, # 18 p. 2543 - 2549
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 4 h; 2: With sodium tetrahydroborate; acetic acid in tetrahydrofuran T=20°C; 2 h; 3: With water; sodium hydrogencarbonate in tetrahydrofuran
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1783137 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
acetic acid in water; isopropyl alcohol
参考文献
LG Chem Investment Ltd.
Patent: US6630593 B1, 2003 ;
反应条件
acetic acid in butan-1-ol 50 h; Ambient temperature;
参考文献
Aulaskari, Paula; Ahlgren, Markku; Rouvinen, Juha; Vainiotalo, Pirjo; Pohjala, Esko; Vepsaelaeinen, Jouko
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 4 p. 1345 - 1354
