TPPD in dichloromethane T=20°C; Friedel-Crafts benzylation; 0.5 h; regioselective reaction;

Pd0(tris(tert-butyl)phosphine)2; sodium hydroxide in tetrahydrofuran; water T=70°C; Suzuki-Miyaura Coupling; 16 h; chemoselective reaction;

triethylamine; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in benzene 14 h; Heating;

diethyl ether

1: bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 4,4'-di-tert-butyl-2,2'-dipyridyl / tetrahydrofuran / 4 h / 50 °C 2: chloro-trimethyl-silane; potassium iodide; water / acetonitrile / 25 °C 3: Pd0(tris(tert-butyl)phosphine)2; sodium hydroxide / tetrahydrofuran; water / 16 h / 70 °C View Scheme

thermally activated clayzic T=40°C; Rate constant;