(4-甲氧基苯基)(2,2,2-三氟乙基)胺合成路线 （共 6 条）
反应条件
1: With borane-THF in tetrahydrofuran
T=20 - 60°C;
2: With water; ammonium chloride in tetrahydrofuran
T=20°C;
参考文献
Katzenellenbogen, John A.; Katzenellenbogen, Benita S.; Compton, Dennis R.
Patent: US2007/21495 A1, 2007 ;
Location in patent: Page/Page column 14; 22; 24-25 ;
US 20070021495 A1
反应条件
5 Pd(II)/C(eggshell); hydrogen in toluene
P=1500.15 Torr;
参考文献
Mimura, Hideyuki; Kawada, Kosuke; Yamashita, Tetsuya; Sakamoto, Takeshi; Kikugawa, Yasuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 4 p. 477 - 486
反应条件
sodium tetrahydroborate in methanol
1 h; Inert atmosphereReflux;
参考文献
Mimura, Hideyuki; Kawada, Kosuke; Yamashita, Tetsuya; Sakamoto, Takeshi; Kikugawa, Yasuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 4 p. 477 - 486
反应条件
1: With L-proline in 1-methyl-pyrrolidin-2-one
T=-20 - 0°C; cross-Mannich reaction;
2: With sodium tetrahydroborate in methanol
T=0°C; 3 h; Further byproducts given;
参考文献
Fustero, Santos; Jimenez, Diego; Sanz-Cervera, Juan F.; Saenchez-Rosello, Maria; Esteban, Elisabet; Simon-Fuentes, Antonio
Organic Letters, 2005 , vol. 7, # 16 p. 3433 - 3436
反应条件
copper(II) bis(trifluoromethanesulfonate) in toluene
T=60°C; Diels-Alder reaction;
参考文献
Xie, Haibo; Zhu, Jiangtao; Chen, Zixian; Li, Shan; Wu, Yongming
Synlett, 2010 , # 17 p. 2659 - 2663
反应条件
1: 90 percent / triphenylphosphine; triethylamine; CCl4 / 3 h / Heating
2: 1 percent Spectr. / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Takagi, Jun; Takihana, Ryozo; Kuwano, Akiko; Uneyama, Kenji
Synthesis, 2007 , # 11 p. 1624 - 1628
