2-氨基-1,7-二氢-7-beta-D-呋喃核糖基-4H-吡咯并[2,3-d]嘧啶-4-酮合成路线 （共 8 条）
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile 1) RT, 1 h; 2) reflux, 4 h;
参考文献
Ramasamy; Imamura; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898
反应条件
sodium hydroxide in 1,4-dioxane 3 h; Heating;
参考文献
Seela; Soulimane; Mersmann; Jurgens
Helvetica Chimica Acta, 1990 , vol. 73, # 7 p. 1879 - 1887
反应条件
1: 2) trifluoroacetic acid / 1) methanol, reflux, 6 h; 2) water, 0-5 deg C, 0.5 h 2: 92 percent / sodium iodide, chlorotrimethylsilane / acetonitrile / 1) RT, 1 h; 2) reflux, 4 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1893 - 1898
反应条件
1: 1) KOH, tris<2-(2-methoxyethoxy)ethyl>amine / 1) MeCN, 10 min, 2) r.t., 20 h 2: 77 percent / 90percent aq. CF3COOH / 1 h / Ambient temperature 3: 61 percent / 2N NaOH / dioxane / 3 h / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, # 7 p. 1879 - 1887
反应条件
1: 1) KOH, tris<2-(2-methoxyethoxy)ethyl>amine / 1) MeCN, 10 min, 2) r.t., 20 h 2: 77 percent / 90percent aq. CF3COOH / 1 h / Ambient temperature 3: 61 percent / 2N NaOH / dioxane / 3 h / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, # 7 p. 1879 - 1887
反应条件
1: 66 percent / NaH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature 2: 81 percent / NaH / 0.5 h / 120 °C 3: 1) 1.2M BCl3, 2) NH3 / 1) CH2Cl2, -78 deg C, 3 h, 2) MeOH View Scheme
参考文献
Chemische Berichte, , vol. 114, # 10 p. 3395 - 3402
反应条件
ammonia; boron trichloride 1) CH2Cl2, -78 deg C, 3 h, 2) MeOH; Yield given. Multistep reaction;
参考文献
Chemische Berichte, , vol. 114, # 10 p. 3395 - 3402
反应条件
1: 81 percent / NaH / 0.5 h / 120 °C 2: 1) 1.2M BCl3, 2) NH3 / 1) CH2Cl2, -78 deg C, 3 h, 2) MeOH View Scheme
参考文献
Chemische Berichte, , vol. 114, # 10 p. 3395 - 3402
