4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=20°C; Product distribution / selectivity;

1.1: iodine; potassium iodide; potassium hydrogencarbonate / tetrahydrofuran; water / 22 h / 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: formic acid; acetic anhydride / 20 h / 20 °C / |Inert atmosphere 2.2: 23 h / 0 - 20 °C / |Inert atmosphere 2.3: 2 h / 0 - 20 °C / pH 4 / |Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethyl ether / 0.5 h / 20 °C / |Inert atmosphere 4.1: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.25 h / -20 - 0 °C / |Inert atmosphere 5.1: dichloromethane / 11 h / 20 °C / |Inert atmosphere 6.1: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere View Scheme

暂无反应条件数据

暂无反应条件数据

T=65°C; P=0.01 - 0.1 Torr; 72 h; 10percent dosage immobilized nonregiospecific yeast lipase from Candida antarctica;

N-bromosuccinmide in ethylene glycol dimethyl ether T=0°C;

1.1: iodine; potassium iodide; potassium hydrogencarbonate / tetrahydrofuran; water / 22 h / 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: formic acid; acetic anhydride / 20 h / 20 °C / |Inert atmosphere 2.2: 23 h / 0 - 20 °C / |Inert atmosphere 2.3: 2 h / 0 - 20 °C / pH 4 / |Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethyl ether / 0.5 h / 20 °C / |Inert atmosphere 4.1: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.25 h / -20 - 0 °C / |Inert atmosphere 5.1: dichloromethane / 11 h / 20 °C / |Inert atmosphere 6.1: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere 7.1: lithium hydroxide hydrate / water; methanol / 1.5 h / 60 °C / |Inert atmosphere View Scheme

in diethyl ether

1.1: iodine; potassium iodide; potassium hydrogencarbonate / tetrahydrofuran; water / 22 h / 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: formic acid; acetic anhydride / 20 h / 20 °C / |Inert atmosphere 2.2: 23 h / 0 - 20 °C / |Inert atmosphere 2.3: 2 h / 0 - 20 °C / pH 4 / |Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethyl ether / 0.5 h / 20 °C / |Inert atmosphere 4.1: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.25 h / -20 - 0 °C / |Inert atmosphere 5.1: sodium dihydrogen phosphate dihydrate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile / 1.5 h / 20 °C / |Inert atmosphere View Scheme

1: With iodine; potassium hydrogencarbonate; potassium iodide in tetrahydrofuran; water T=20°C; 22 h; Inert atmosphere; 2: With potassium carbonate in methanol Inert atmosphere;