1: thionylchloride / 2 h / Heating 2: 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 2 h / temperature: below 0 deg C View Scheme

1: 1.) 4N NaOH / 1.) ca. 5 deg C, 15 min 2.) ethyl acetate, Et2O, 5 min 2: 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 2 h / temperature: below 0 deg C View Scheme

benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane 2 h; temperature: below 0 deg C;

(i) 1-(4-chloro-phenyl)-3-(4-methyl-piperazin-1-yl)-prop-2-yn-1-one, CH2Cl2, (ii) /BRN= 3913214/, 4-methyl-morpholine; Multistep reaction;