1-(4-硝基苯基)-1H-1,2,4-噻唑合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C;
参考文献
Kitazaki, Tomoyuki; Ichikawa, Takashi; Tasaka, Akihiro; Hosono, Hiroshi; Matsushita, Yoshihiro; Hayashi, Ryogo; Okonogi, Kenji; Itoh, Katsumi
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1935 - 1946
反应条件
potassium hydroxide; ethanol 6 h; Heating;
参考文献
Australian Journal of Chemistry, , vol. 46, # 4 p. 417 - 425
反应条件
copper(l) chloride; sodium hydroxide; Hdppa in dimethyl sulfoxide
T=120°C; 14 h; Inert atmosphereSealed tube;
参考文献
Sajadi, S. Mohammad; Maham, Mehdi
Journal of Chemical Research, 2014 , vol. 38, # 2 p. 128 - 129
反应条件
Cu(I) 3-methylsalicylate; potassium carbonate in dimethyl sulfoxide
T=110°C; 3 h;
参考文献
Farahat, Abdelbasset A.; Boykin, David W.
Tetrahedron Letters, 2014 , vol. 55, # 19 p. 3049 - 3051
反应条件
potassium carbonate in dimethyl sulfoxide
8 h;
参考文献
Mackay, Maureen F.; Trantino, Giuseppe J.; Wilshire, John F. K.
Australian Journal of Chemistry, 1993 , vol. 46, # 4 p. 417 - 425
反应条件
sulfuric acid; nitric acid
T=0 - 20°C; 24 h;
参考文献
Kommu, Nagarjuna; Ghule, Vikas D.; Kumar, A. Sudheer; Sahoo, Akhila K.
Chemistry - An Asian Journal, 2014 , vol. 9, # 1 p. 166 - 178
反应条件
in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Merck, Sharp and Dohme Ltd.
Patent: US5567726 A1, 1996 ;
反应条件
1: copper(l) iodide; potassium phosphate / N,N-dimethyl-formamide / 40 h / 50 °C / |Inert atmosphere
2: sulfuric acid; nitric acid / 24 h / 0 - 20 °C
View Scheme
参考文献
Kommu, Nagarjuna; Ghule, Vikas D.; Kumar, A. Sudheer; Sahoo, Akhila K.
Chemistry - An Asian Journal, 2014 , vol. 9, # 1 p. 166 - 178
反应条件
T=120°C; 12 h; Inert atmosphere;
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Lopez Cara, Carlota; Carrion, Maria Dora; Brancale, Andrea; Hamel, Ernest; Chen, Longchuan; Bortolozzi, Roberta; Basso, Giuseppe; Viola, Giampietro
Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4248 - 4258
反应条件
in N,N-dimethyl-formamide
16 h; Ambient temperature;
参考文献
Street; Baker; Davey; Guiblin; Jelley; Reeve; Routledge; Sternfeld; Watt; Beer; Middlemiss; Noble; Stanton; Scholey; Hargreaves; Sohal; Graham; Matassa
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1799 - 1810
