反应条件
1: sodium hexamethyldisilazide / tetrahydrofuran / -78 - 20 °C 2: Me2AlCl / 20 °C 3: tetrahydrofuran / 2 h / 0 °C 4: LiBH(sec-Bu)3 / tetrahydrofuran / 0.5 h / 0 °C 5: Et3N / ethyl acetate / 0.5 h / 0 °C 6: NaN3 / dimethylformamide / 1 h / 120 °C 7: H2 / PtO2 / ethyl acetate / 24 h 8: tris(dibenzylideneacetone)dipalladium chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide; H2O / 24 h / 120 °C 9: HCl / ethyl acetate / 0.5 h / 20 °C 10: N-methylmorpholine; PyBOP / CH2Cl2 / 20 °C View Scheme
参考文献
Lin, Linus S.; Lanza Jr., Thomas J.; Jewell, James P.; Liu, Fing; Shah, Shrenik K.; Qi, Hongbo; Tong, Xinchun; Wang, Junying; Xu, Suoyu S.; Fong, Tung M.; Shen, Chun-Pyn; Lao, Julie; Xiao, Jing Chen; Shearman, Lauren P.; Stribling, D. Sloan; Rosko, Kimberly; Strack, Alison; Marsh, Donald J.; Feng, Yue; Kumar, Sanjeev; Samuel, Koppara; Yin, Wenji; Van Der Ploeg, Lex H. T.; Goulet, Mark T.; Hagmann, William K.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7584 - 7587