2ˊ-脱氧胞苷-3ˊ-一磷酸合成路线 （共 16 条）
反应条件
cerium(III) chloride; HEPES buffer in water T=50°C; Rate constant;
参考文献
Schuler; Budiawan; Eder
Chemical research in toxicology, 1999 , vol. 12, # 4 p. 335 - 340
反应条件
1: C49H62N23O28P5 With N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide
T=17°C; pH=6; 48 h;
2: C9H15N3O10P2*C6H15N With 1,4-dithio-DL-threitol; adenosine 5'-triphosphoric acid; manganese (II) chloride; N,N'-bis(3-aminopropyl)-1,4-butanediamine
T=48°C; pH=8; 17 h;
3: With alkaline phosphatase
T=37°C; pH=8; 1 h; Further stages.;
参考文献
Schmitz; Reetz
Organic letters, 1999 , vol. 1, # 11 p. 1729 - 1731
反应条件
pyridine; ammonium hydroxide; acetic acid
1.) 50 deg C, 12 h, 2.) 30 min; Multistep reaction;
参考文献
Jankowska, Jadwiga; Stawinski, Jacek
Bulletin of the Polish Academy of Sciences, Chemistry, 1983 , vol. 31, # 1-2 p. 17 - 22
反应条件
1: TPS-TAZ / pyridine / 2 h / 25 °C
2: NaOH / ethanol; pyridine / 0.33 h / 25 °C
3: CH3COOH / H2O / 0.5 h / 25 °C
4: NH4OH / H2O / 6 h / 65 °C
View Scheme
参考文献
Taktakishvili; Nair
Tetrahedron Letters, 2000 , vol. 41, # 37 p. 7173 - 7176
反应条件
1: Pd(P(C6H5)3)4, P(C6H5)3, HCOOH, n-C4H9NH2 / tetrahydrofuran / 3 h / 50 °C
2: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C
View Scheme
参考文献
Hayakawa, Y.; Wakabayashi, S.; Nobori, T.; Noyori, R.
Tetrahedron Letters, 1987 , vol. 28, # 20 p. 2259 - 2262
反应条件
1: 97 percent / t-butylmagnesium chloride / tetrahydrofuran / 0.3 h / Ambient temperature
2: Pd(P(C6H5)3)4, P(C6H5)3, HCOOH, n-C4H9NH2 / tetrahydrofuran / 3 h / 50 °C
3: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C
View Scheme
参考文献
Hayakawa, Y.; Wakabayashi, S.; Nobori, T.; Noyori, R.
Tetrahedron Letters, 1987 , vol. 28, # 20 p. 2259 - 2262
反应条件
formic acid
Yield given;
参考文献
Hayakawa, Yoshihiro; Kawai, Rie; Wakabayashi, Shigeharu; Uchiyama, Mamoru; Noyori, Ryoji
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 441 - 449
反应条件
1: pyridine / und Erwaermen des Reaktionsprodukts mit wss.Essigsaeure
2: palladium/charcoal; ethanol; water / Hydrogenation
View Scheme
参考文献
Michelson; Todd
Journal of the Chemical Society, 1954 , p. 34,37
反应条件
1: pyridine
2: pyridine / und Erwaermen des Reaktionsprodukts mit wss.Essigsaeure
3: palladium/charcoal; ethanol; water / Hydrogenation
View Scheme
参考文献
Michelson; Todd
Journal of the Chemical Society, 1954 , p. 34,37
反应条件
ammonium hydroxide; 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride
1) benzene, 6 h, 2) 80percent acetic acid; Yield given. Multistep reaction;
参考文献
Palissa, Manfred; Koenig, Joachim; Cech, Dieter; Schubert, Frank
Zeitschrift fuer Chemie (Stuttgart, Germany), 1988 , vol. 28, # 5 p. 184 - 185
