1-甲基-4-(2-硝基苯基)哌嗪合成路线 （共 7 条）
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol; water T=20 - 80°C; 2: With sodium hydroxide in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 17 p. 5221 - 5224
反应条件
PS-morpholine in chloroform
T=50°C; 2 h;
参考文献
Patch, Raymond J.; Brandt, Benjamin M.; Asgari, Davoud; Baindur, Nand; Chadha, Naresh K.; Georgiadis, Taxiarchis; Cheung, Wing S.; Petrounia, Ioanna P.; Donatelli, Robert R.; Chaikin, Margery A.; Player, Mark R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6070 - 6074
反应条件
T=120°C; 3 h; Neat (no solvent);
参考文献
Park, Chul Min; Kim, So Young; Park, Woo Kyu; Choi, Jung Hwan; Seong, Churl Min
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5221 - 5224
反应条件
potassium acetate; 1-n-butyl-3-methylimidazolium tetrafluoroborate
0.025 h; microwave irradiation;
参考文献
Angrish, Chetna; Kumar, Anil; Chauhan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 7 p. 1515 - 1518
参考文献
Pfizer Inc.
Patent: US6258953 B1, 2001 ;
US 6258953 B1
参考文献
Pfizer INC
Patent: US6277852 B1, 2001 ;
US 6277852 B1
参考文献
Albro et al.
Journal of Organic Chemistry, 1949 , vol. 14, p. 771,772
