4-溴噻吩-2-甲酸甲酯合成路线 （共 10 条）
反应条件
sulfuric acid in methanol T=65°C; 17 h;
参考文献
Dublanchet, Anne-Claude; Compere, Delphine; Cluzeau, Philippe; Blais, Stephane; Denis, Alexis; Ducrot, Pierre; Courte, Karine; Descamps, Sophie
Patent: US2004/72871 A1, 2004 ;
Location in patent: Page/Page column 29 ;
反应条件
sulfuric acid T=25 - 50°C; 12 h;
参考文献
GLAXOSMITHKLINE LLC; ROUSE, Meagan, B.; SEEFELD, Mark, Andrew
Patent: WO2010/93885 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
WO 2010/093885 A1
反应条件
1: 93 percent / NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0 - 20 °C 2: 95 percent / SOCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 3 p. 491 - 495
反应条件
1: 90 percent / Zn, AcOH / H2O / 0.25 h / Heating 2: 1.) SOCl2 / 1.) CHCl3, reflux, 40 min, 2.) CHCl3, 2 h, reflux View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 5 p. 1801 - 1824
反应条件
1 h; Heating; Yield given;
参考文献
Archiv der Pharmazie, , vol. 331, # 12 p. 405 - 411
反应条件
potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=85°C; 40 h;
参考文献
MERCK SHARP and DOHME LIMITED; MERCK and CO., INC.
Patent: WO2007/85873 A1, 2007 ;
Location in patent: Page/Page column 18 ;
WO 2007/085873 A1
参考文献
3-DIMENSIONAL PHARMACEUTICALS, INC.
Patent: WO2003/99805 A1, 2003 ;
Location in patent: Page 151 ;
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
T=80°C; 3 h;
参考文献
WARNER-LAMBERT COMPANY LLC.
Patent: WO2004/14381 A2, 2004 ;
Location in patent: Page/Page column 42-43 ;
反应条件
sodium carbonate; methyl (triphenylphosphoranylidene)acetate in tetrahydrofuran; water
T=90 - 100°C;
参考文献
S*BIO PTE LTD
Patent: WO2005/40161 A1, 2005 ;
Location in patent: Page/Page column 77-78 ;
反应条件
sodium hydride; sodium iodide; copper(II) oxide
1.) dioxane, 1h, reflux, 2.) dioxane, 6 h, reflux; Yield given. Multistep reaction;
参考文献
Binder, Dieter; Prager, Bernhard C.; Noe, Christian R.
Journal of Chemical Research, Miniprint, 1981 , # 5 p. 1801 - 1824
