5-溴噻吩-2-羧酸甲酯合成路线

参考文献

Shih, Chuan; Gossett, Lynn S.; Worzalla, John F.; Rinzel, Sharon M.; Grindey, Gerald B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1109 - 1116

7311-63-95-溴-2-羧基噻吩+

74-88-4甲基碘

62224-19-55-溴噻吩-2-羧酸甲酯

参考文献

Apperloo, Joke J.; Janssen, Rene A.J.; Malenfant, Patrick R.L.; Groenendaal, Lambertus; Frechet, Jean M.J.
Journal of the American Chemical Society, 2000 , vol. 122, # 29 p. 7042 - 7051

7311-63-95-溴-2-羧基噻吩

62224-19-55-溴噻吩-2-羧酸甲酯

参考文献

Agouron Pharmaceuticals, Inc.
Patent: US5739141 A1, 1998 ;

7311-63-95-溴-2-羧基噻吩+

18107-18-1三甲基硅烷化重氮甲烷

62224-19-55-溴噻吩-2-羧酸甲酯

参考文献

CAYMAN CHEMICAL COMPANY, INC.; MYOMETRICS, LLC; BARRETT, Stephen, Douglas; CISKE, Fred, Lawrence; COLOMBO, Joseph, Michael; ENDRES, Gregory, William; GERMAIN, Bradlee, David; KORNILOV, Andriy; KRAMER, James, Bernard; UZIEBLO, Adam; OWEN, Thomas, Allen; O'MALLEY, James, Paul
Patent: WO2014/15246 A1, 2014 ;
Location in patent: Paragraph 0498-0499 ;

7311-63-95-溴-2-羧基噻吩+

75-36-5乙酰氯

62224-19-55-溴噻吩-2-羧酸甲酯

参考文献

Allergan, Inc.
Patent: US2007/203222 A1, 2007 ;
Location in patent: Page/Page column 18 ;

67-56-1甲醇+

31555-60-95-溴噻吩-2-羰酰氯

62224-19-55-溴噻吩-2-羧酸甲酯

参考文献

Archiv der Pharmazie, , vol. 331, # 12 p. 405 - 411

1003-09-42-溴噻吩+

67-56-1甲醇+