5-溴噻吩-2-羧酸甲酯合成路线 （共 24 条）
反应条件
T=30 - 45°C; Rate constant;
参考文献
Nippon Kagaku Zasshi, , vol. 77, p. 804,807
Chem.Abstr., , p. 9066
反应条件
sodium tetrahydroborate; N,N,N',N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; Reagent/catalystTime; chemoselective reaction;
参考文献
Chelucci, Giorgio; Baldino, Salvatore; Ruiu, Andrea
Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9921 - 9925,5
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 90 °C / Inert atmosphere 2: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 24 h / Inert atmosphere View Scheme
参考文献
Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L.
ChemMedChem, 2011 , vol. 6, # 2 p. 362 - 377
反应条件
1.1: 60 percent / HNO3; H2SO4 2.1: 94 percent / Zn; HCl / ethanol 3.1: NaNO2; HCl; HPF6 3.2: 180 - 200 °C 4.1: 100 percent / Br2 / CHCl3 / 2.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 50 p. 8797 - 8800
反应条件
sulfuric acid; nitric acid
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
sodium tetrahydroborate in tetrahydrofuran
参考文献
Lin, Yu-Sheng; Lin, Chiao-Yang; Huang, Deng-Yi; Tsai, Thomas Y. R.
Journal of the Chinese Chemical Society, 2005 , vol. 52, # 5 p. 849 - 852
反应条件
1: 60 percent / HNO3; H2SO4 2: 94 percent / Zn; HCl / ethanol View Scheme
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1.1: 60 percent / HNO3; H2SO4 2.1: 94 percent / Zn; HCl / ethanol 3.1: NaNO2; HCl; HPF6 3.2: 180 - 200 °C View Scheme
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine / 18 h / 20 °C 2: sodium hydroxide; water / methanol / 5 h / 0 - 20 °C View Scheme
参考文献
Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; Iida, Shinsuke; Ueda, Ryuzo; Shirahige, Katsuhiko; Miyata, Naoki
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9562 - 9575
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 90 °C / Inert atmosphere 2: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 24 h / Inert atmosphere View Scheme
参考文献
ChemMedChem, , vol. 6, # 2 p. 362 - 377
