2,5-二氯-2,5-二甲基己烷合成路线 （共 77 条）
反应条件
aluminium trichloride in dichloromethane 1.) RT, 30 min, 2.) reflux, 15 min;
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
aluminium trichloride in hexane 1.) RT, 30 min, 2.) reflux, 15 min;
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
aluminium trichloride 12 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 56, # 15 p. 4706 - 4713
反应条件
AlCl3, aluminium chloride in toluene 0.416667 h;
参考文献
EP1105120 B1, ;
Page/Page column 13 ;
EP 1105120 B1
反应条件
hydrogenchloride; AlCl3 in toluene
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / |Reflux 2.1: palladium dichloride; copper(l) iodide; triethylamine / methanol / 20 °C / |Sonication 3.1: sodium hydride / toluene / |Reflux 3.2: 20 °C 4.1: n-butyllithium / tetrahydrofuran / -78 °C 4.2: 20 °C 5.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 5.2: 2 h / |Reflux; |Inert atmosphere 6.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 7.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 8.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 9.1: water; hydrogenchloride / 3 h / |Reflux View Scheme
参考文献
Guerrero Jr., Palimecio G.; De Oliveira, Paulo R.; Baroni, Adriano C.M.; Marques, Francisco A.; Labes, Ricardo; Hurtado, Gabriela R.; Dabdoub, Miguel J.
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5302 - 5305
反应条件
bromine; sodium hydrogencarbonate; aluminium trichloride in benzene
参考文献
Centre Europeen de Bioprospective-Ceb
Patent: US6265423 B1, 2001 ;
US 6265423 B1
反应条件
aluminium trichloride 24 h; Heating;
参考文献
Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Himi, Toshiyuki; Shudo, Koichi
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2182 - 2192
反应条件
mit viel AlCl3; dann bei Siedetemperatur; reagiert Analog mit anderen aromatischen Kohlenwasserstoffen;
参考文献
Bruson; Kroeger
Journal of the American Chemical Society, 1940 , vol. 62, p. 36,43
反应条件
soda lime T=255 - 270°C; P=12 - 20 Torr;
参考文献
Staudinger; Ruzicka
Helvetica Chimica Acta, 1924 , vol. 7, p. 385
