2,5-二氯-2,5-二甲基己烷合成路线 （共 77 条）
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 85 percent / Br2; AlCl3 / CH2Cl2 3: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 4: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C 5: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C View Scheme
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
1: 81.9 percent / AlCl3 / 24 h / Heating 2: 80.4 percent / AlCl3 / 1,2-dichloro-ethane View Scheme
参考文献
Selen Gurkan-Alp; Mumcuoglu, Mine; Andac, Cenk A.; Dayanc, Emre; Cetin-Atalay, Rengul; Buyukbingol, Erdem
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 346 - 354
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 12 h / |Reflux 2: AlCl3, aluminium chloride / dichloromethane / 2 h / |Reflux View Scheme
参考文献
Toyama, Hirozumi; Nakamura, Masaharu; Nakamura, Masahiko; Matsumoto, Yotaro; Nakagomi, Madoka; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 6 p. 1948 - 1959
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C View Scheme
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 85 percent / Br2; AlCl3 / CH2Cl2 3: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 4: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C 3: 100 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C View Scheme
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C 3: NaNH2 / tetrahydrofuran View Scheme
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 85 percent / Br2; AlCl3 / CH2Cl2 3: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 4: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C 5: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C 6: H2O View Scheme
参考文献
Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C 3: NaNH2 / tetrahydrofuran 4: 65 percent / Et2Zn / CH2Cl2 View Scheme
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
