N-α-苄氧羰基-L-2,4-二氨基丁酸合成路线 (共 7 条)
反应条件
[bis(acetoxy)iodo]benzene in tetrahydrofuran; water T=4°C; Hofmann reaction; 8 h;
参考文献
Andruszkiewicz, Ryszard; Rozkiewicz, Dorota
Synthetic Communications, 2004 , vol. 34, # 6 p. 1049 - 1056
反应条件
pyridine; bis-[(trifluoroacetoxy)iodo]benzene 24 h; Ambient temperature;
参考文献
Anteunis, M. J. O.; Auwera, C. Van der; Vanfleteren, L.; Borremans, F.
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 2 p. 135 - 148
反应条件
triethylamine in tert-butyl alcohol
参考文献
Broadbent,W. et al.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 2632 - 2636
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 3 h;
参考文献
Marrano; de Macedo; Gagnon; Lapierre; Gravel; Keillor
Bioorganic and medicinal chemistry, 2001 , vol. 9, # 12 p. 3231 - 3241
反应条件
triethylamine in water; acetone
参考文献
Kazmierski, Wieslaw M.
Tetrahedron Letters, 1993 , vol. 34, # 28 p. 4493 - 4496
反应条件
1: hydrogenchloride / 16 h / 20 °C / |Inert atmosphere 2: triethylamine / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Long, Bohua; Tang, Shoubin; Chen, Ligong; Qu, Shiwei; Chen, Bo; Liu, Junyang; Maguire, Anita R.; Wang, Zhuo; Liu, Yuqing; Zhang, Hui; Xu, Zhengshuang; Ye, Tao
Chemical Communications, 2013 , vol. 49, # 29 p. 2977 - 2979
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C;
2: With hydrogenchloride in water
pH=~ 2;
参考文献
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Patent: WO2009/18549 A1, 2009 ;
Location in patent: Page/Page column 58 ;