7-氟-6-甲氧基-4-氧代-1,4-二氢-3-喹啉甲腈合成路线 （共 4 条）
反应条件
1.1: 77 percent / POCl3 / 0.5 h / Heating 2.1: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C 3.1: NaH / dimethylformamide / 0.08 h / 100 °C 3.2: 55 percent / dimethylformamide / 2 h / 120 °C View Scheme
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
反应条件
trichlorophosphate 0.5 h; Heating;
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
反应条件
1: 77 percent / POCl3 / 0.5 h / Heating
2: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C
View Scheme
参考文献
Boschelli, Diane H.; Wang, Yanong D.; Johnson, Steve; Wu, Biqi; Ye, Fei; Barrios Sosa, Ana Carolina; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1599 - 1601
反应条件
1: With trichlorophosphate
T=115°C; 1.5 h;
2: With ammonia in water
T=0°C;
参考文献
Wyeth Holdings Corporation
Patent: US2003/212276 A1, 2003 ;
Location in patent: Page/Page column 12 ;
